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How to get fromPrague to Mainz, Hauptbahnhofby subway, plane, bus, train, or car

Find Transport to Mainz, Hauptbahnhof

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There are 7 ways to get from Prague to Mainz, Hauptbahnhof by subway, plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Václav Havel Airport Prague, fly

    best
    1. Take the subway from Staroměstská to Nádraží Veleslavínsubway subway
    2. Fly from Václav Havel Airport Prague (PRG) to Frankfurt (FRA)plane plane PRG - FRA
    4h 3m
    €62–166

  2. Bus, train

    cheapest
    1. Take the bus from Prague Florenc Bus Station to Frankfurt am Mainbus bus
    2. Take the train from Frankfurt Konstablerwache to Mainz, Hauptbahnhoftrain train S8
    9h 45m
    €30–55

  3. Bus

    1. Take the bus from Prague to Mainz central train stationbus bus N1310
    8h 5m
    €45–85

  4. Train via Nuremberg

    1. Take the train from Praha Hlavni Nadrazi to Schwandorftrain train Ec
    2. Take the train from Schwandorf to Nürnberg Hbftrain train
    3. Take the train from Nürnberg Hbf to Frankfurttrain train 41
    9h 10m
    €123–350

  5. Drive 542.1 km

    1. Drive from Prague to Mainz, Hauptbahnhofcar car 542.1 km
    4h 36m
    €84–120

  6. Train to Dresden Airport, fly

    1. Take the train from Praha-Holesovice to Dresden Hbftrain train
    2. Fly from Dresden Airport (DRS) to Frankfurt (FRA)plane plane DRS - FRA
    5h 30m
    €170–389

  7. Train

    1. Take the train from Praha Hlavní nádraží to Frankfurttrain train Drf
    11h 52m

Prague to Mainz, Hauptbahnhof by bus

Calendar7Weekly Buses
Duration8h 5mAverage Duration
Ticket€45Cheapest Price
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Questions & Answers

Map of how to get from Prague to Mainz, Hauptbahnhof.ExpandLaunch map view
  • Distance: 448.5 km
  • Duration: 4h 3m

What companies run services between Prague, Czechia and Mainz, Hauptbahnhof, Germany?

FlixBus operates a bus from Prague to Mainz central train station once daily. Tickets cost €45–85 and the journey takes 8h 5m. Alternatively, you can take a train from Praha Hlavni Nadrazi to Mainz, Hauptbahnhof via Schwandorf, Nürnberg Hbf, and Frankfurt in around 9h 10m.

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