Rome2Rio

How to get fromPrague to Mendrisioby plane, train, bus, or car

Find Transport to Mendrisio

See all options

There are 9 ways to get from Prague to Mendrisio by plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Milano Malpensa Airport, train

    best
    1. Fly from Václav Havel Airport Prague (PRG) to Milano Malpensa Airport (MXP)plane plane PRG - MXP
    2. Take the train from Malpensa Aeroporto T1 to Mendrisiotrain train
    5h 25m
    CHF 36–208

  2. Bus

    1. Take the bus from Prague to Comobus bus FlixBus N1308
    13h 7m
    CHF 69–103

  3. Train via Munich

    1. Take the train from Praha Hlavni Nadrazi to Muenchen Hbftrain train Ec
    2. Take the train from München Hbf to St. Margrethen SGtrain train 88
    3. Take the train from St. Margrethen SG to Zürich HBtrain train Ec
    4. Take the train from Zürich HB to Luganotrain train Ec / ...
    13h 55m
    CHF 219–353

  4. Drive  806.6 km

    1. Drive from Prague to Mendrisiocar car 806.6 km
    7h 31m
    CHF 135–195

  5. Fly to Il Caravaggio International Airport, bus, train

    1. Fly from Václav Havel Airport Prague (PRG) to Il Caravaggio International Airport (BGY)plane plane PRG - BGY
    2. Take the bus from Milan Bergamo Orio al Serio Airport to Piazza Luigi di Savoiabus bus
    3. Take the train from Milano Centrale to Mendrisiotrain train
    6h 25m
    CHF 71–279

  6. Fly to Milan Linate Airport, train

    1. Fly from Václav Havel Airport Prague (PRG) to Milan Linate Airport (LIN)plane plane PRG - LIN
    2. Take the train from Monza to Mendrisiotrain train
    7h 32m
    CHF 97–252

  7. Fly to Zurich Airport, train

    1. Fly from Václav Havel Airport Prague (PRG) to Zurich Airport (ZRH)plane plane PRG - ZRH
    2. Take the train from Zürich HB to Luganotrain train
    6h 46m
    CHF 136–306

  8. Bus via Sankt Gallen

    1. Take the bus from Praha, ÚAN Florenc to Sankt Gallenbus bus
    2. Take the bus from St. Gallen to Chiassobus bus
    14h 55m
    CHF 110–112

  9. Train

    1. Take the train from Praha Hlavni Nadrazi to Zuerich Hbtrain train Ec
    2. Take the train from Zürich HB to Luganotrain train Ec / ...
    18h 18m
    CHF 302–373

Prague to Mendrisio by bus

Calendar11Weekly Buses
Duration13h 7mAverage Duration
TicketCHF 69Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Prague to Mendrisio.ExpandLaunch map view
  • Distance: 720.1 km
  • Duration: 5h 25m

What companies run services between Prague, Czechia and Mendrisio, Switzerland?

FlixBus operates a bus from Prague to Como twice daily. Tickets cost CHF 65–100 and the journey takes 12h. Alternatively, you can take a train from Praha Hlavni Nadrazi to Mendrisio via Muenchen Hbf, München Hbf, St. Margrethen SG, Zürich HB, and Lugano in around 13h 55m.

Airlines
Train operators
Bus operators

Want to know more about travelling around Switzerland

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Italy Travel Guides

Read the travel guideItaly Travel Guides

Booking & Getting There