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How to get fromPrague to Mendrisioby plane, train, bus, or car

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There are 8 ways to get from Prague to Mendrisio by plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Milano Malpensa Airport, train

    best
    1. Fly from Václav Havel Airport Prague (PRG) to Milano Malpensa Airport (MXP)plane plane PRG - MXP
    2. Take the train from Malpensa Aeroporto T1 to Mendrisiotrain train
    5h 25m
    CHF 41–204

  2. Bus

    1. Take the bus from Prague to Comobus bus FlixBus N1308
    12h 22m
    CHF 61–107

  3. Train

    1. Take the train from Praha Hlavni Nadrazi to Zuerich Hbtrain train Ec
    2. Take the train from Zürich HB to Luganotrain train Ec / ...
    17h 18m
    CHF 282–588

  4. Drive 806.5 km

    1. Drive from Prague to Mendrisiocar car 806.5 km
    7h 29m
    CHF 132–190

  5. Fly to Il Caravaggio International Airport, bus, train

    1. Fly from Václav Havel Airport Prague (PRG) to Il Caravaggio International Airport (BGY)plane plane PRG - BGY
    2. Take the bus from Milan Bergamo Orio al Serio Airport to Piazza Luigi di Savoiabus bus
    3. Take the train from Milano Centrale to Mendrisiotrain train
    6h 32m
    CHF 70–277

  6. Fly to Milan Linate Airport, train

    1. Fly from Václav Havel Airport Prague (PRG) to Milan Linate Airport (LIN)plane plane PRG - LIN
    2. Take the train from Monza to Mendrisiotrain train
    7h 37m
    CHF 97–233

  7. Fly to Zurich Airport, train

    1. Fly from Václav Havel Airport Prague (PRG) to Zurich Airport (ZRH)plane plane PRG - ZRH
    2. Take the train from Zürich HB to Luganotrain train
    6h 46m
    CHF 146–402

  8. Bus via Sankt Gallen

    1. Take the bus from Praha, ÚAN Florenc to Sankt Gallenbus bus
    2. Take the bus from St. Gallen to Chiassobus bus
    14h 55m
    CHF 105–107

Prague to Mendrisio by bus and train

Calendar7Weekly Services
Duration12h 22mAverage Duration
TicketCHF 61Cheapest Price
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Questions & Answers

Map of how to get from Prague to Mendrisio.ExpandLaunch map view
  • Distance: 720.1 km
  • Duration: 5h 25m

What companies run services between Prague, Czechia and Mendrisio, Switzerland?

FlixBus operates a bus from Prague to Como once daily. Tickets cost CHF 55–95 and the journey takes 12h. Alternatively, you can take a train from Praha Hlavni Nadrazi to Mendrisio via Zuerich Hb, Zürich HB, and Lugano in around 17h 18m.

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