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How to get fromPresque Isle to St. Louisby car, plane, bus, train, bus (Amtrak, Greyhound, Flixbus), or bus (Amtrak, Flixbus)

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There are 7 ways to get from Presque Isle to St. Louis by car, plane, bus, train, bus (Amtrak, Greyhound, Flixbus), or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Fredericton International Airport, fly

    best
    1. Drive from Presque Isle to Fredericton-Airport-YFCcar car
    2. Fly from Fredericton International Airport (YFC) to Lambert–St. Louis International Airport (STL)plane plane YFC - STL
    11h 9m
    $190–792

  2. Fly from Presque Isle

    cheapest
    1. Fly from Presque Isle (PQI) to Lambert–St. Louis International Airport (STL)plane plane PQI - STL
    5h 46m
    $170–762

  3. Bus, train

    1. Take the bus from Presque Isle, Maine to Bangor, MEbus bus
    2. Take the bus from Bangor Transportation Center to Boston, MA - South Stationbus bus
    3. Take the train from Boston to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to St. Louistrain train
    37h 58m
    $446–931

  4. Bus

    1. Take the bus from Presque Isle, Maine to Bangor, MEbus bus
    2. Take the bus from Bangor Transportation Center to Boston, MA - South Stationbus bus
    3. Take the bus from Boston to Newark Penn Stationbus bus
    4. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    38h 40m
    $241–456

  5. Drive 1,453.2 mi

    1. Drive from Presque Isle to St. Louiscar car 1,453.2 mi
    26h 43m
    $266–384

  6. Bus to Bangor, fly

    1. Take the bus from Presque Isle, Maine to Bangor, MEbus bus
    2. Fly from Bangor (BGR) to Lambert–St. Louis International Airport (STL)plane plane BGR - STL
    10h 32m
    $271–1,136

  7. Bus via Auburn Gresham

    1. Take the bus from Presque Isle, Maine to Bangor, MEbus bus
    2. Take the bus from Bangor Transportation Center to Boston, MA - South Stationbus bus
    3. Take the bus from Boston to New York Midtownbus bus
    4. Take the bus from New York Midtown to Chicagobus bus
    5. Take the bus from Chicago to St Louis Bus Stationbus bus
    41h 38m
    $276–456

Presque Isle to St. Louis by bus and train

Calendar7Weekly Services
Duration37h 58mAverage Duration
Ticket$446Cheapest Price
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Questions & Answers

Map of how to get from Presque Isle to St. Louis.ExpandLaunch map view
  • Distance: 1,439.3 mi
  • Duration: 11h 9m

What companies run services between Presque Isle, ME, USA and St. Louis, MO, USA?

You can take a bus from Presque Isle, Maine to St Louis Bus Station via Bangor, ME, Bangor Transportation Center, Boston, MA - South Station, Boston, and Newark Penn Station in around 38h 40m. Alternatively, JetBlue Airways and Southwest Airlines fly from Presque Isle (PQI) to Lambert–St. Louis International Airport (STL) 6 times a week.

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