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How to get fromPresque Isle to St. Louisby plane, bus, train, bus (Amtrak, Greyhound, Flixbus), car, or bus (Amtrak, Flixbus)

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There are 7 ways to get from Presque Isle to St. Louis by plane, bus, train, bus (Amtrak, Greyhound, Flixbus), car, or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Presque Isle

    best
    1. Fly from Presque Isle (PQI) to Lambert–St. Louis International Airport (STL)plane plane PQI - STL
    6h 56m
    $160–762

  2. Bus, train

    1. Take the bus from Presque Isle, Maine to Bangor, MEbus bus
    2. Take the bus from Bangor Transportation Center to Boston, MA - South Stationbus bus
    3. Take the train from Boston to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to St. Louistrain train
    37h 53m
    $381–871

  3. Bus

    1. Take the bus from Presque Isle, Maine to Bangor, MEbus bus
    2. Take the bus from Bangor Transportation Center to Boston, MA - South Stationbus bus
    3. Take the bus from Boston to Newark Penn Stationbus bus
    4. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    38h 35m
    $251–416

  4. Drive  1,452.5 mi

    1. Drive from Presque Isle to St. Louiscar car 1,452.5 mi
    26h 11m
    $266–383

  5. Bus to Bangor, fly

    1. Take the bus from Presque Isle, Maine to Bangor, MEbus bus
    2. Fly from Bangor (BGR) to Lambert–St. Louis International Airport (STL)plane plane BGR - STL
    11h 51m
    $171–736

  6. Bus to Fredericton International Airport, fly

    1. Take the bus from Perth Andover to Oromoctobus bus
    2. Fly from Fredericton International Airport (YFC) to Lambert–St. Louis International Airport (STL)plane plane YFC - STL
    15h 16m
    $214–904

  7. Bus via Auburn Gresham

    1. Take the bus from Presque Isle, Maine to Bangor, MEbus bus
    2. Take the bus from Bangor Transportation Center to Boston, MA - South Stationbus bus
    3. Take the bus from Boston to New York Midtownbus bus
    4. Take the bus from New York Midtown to Chicagobus bus
    5. Take the bus from Chicago to St Louis Bus Stationbus bus
    41h 40m
    $281–441

Presque Isle to St. Louis by bus and train

Calendar7Weekly Services
Duration37h 53mAverage Duration
Ticket$381Cheapest Price
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Comparing Your Travel Options

Map of how to get from Presque Isle to St. Louis.ExpandLaunch map view
  • Distance: 1,269.2 mi
  • Duration: 6h 56m

What companies run services between Presque Isle, ME, USA and St. Louis, MO, USA?

JetBlue Airways and Southwest Airlines fly from Presque Isle (PQI) to Lambert–St. Louis International Airport (STL) 5 times a week. Alternatively, you can take a bus from Presque Isle, Maine to St Louis Bus Station via Bangor, ME, Bangor Transportation Center, Boston, MA - South Station, Boston, and Newark Penn Station in around 38h 35m.

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