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How to get fromPuebla to Panama Cityby plane, bus, or car

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There are 6 ways to get from Puebla to Panama City by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Hermanos Serdán International Airport

    best
    1. Fly from Hermanos Serdán International Airport (PBC) to Tocumen International Airport (PTY)plane plane PBC - PTY
    9h 33m
    $181–644

  2. Bus via San Cristóbal de las Casas

    1. Take the bus from Puebla to San Cristóbal de las Casasbus bus
    2. Take the bus from San Cristóbal de las Casas to Panajachelbus bus
    3. Take the bus from Panajachel to San Salvadorbus bus
    4. Take the bus from San Salvador to San Josébus bus
    5. Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus bus
    2d 15h
    $256–304

  3. Drive 3,034.5 km

    1. Drive from Puebla to Panama Citycar car 3,034.5 km
    43h 39m
    $416–600

  4. Bus to Benito Juárez International Airport, fly

    1. Take the bus from Puebla Terminal CAPU to Terminal Central de Autobuses del Nortebus bus
    2. Fly from Benito Juárez International Airport (MEX) to Tocumen International Airport (PTY)plane plane MEX - PTY
    8h 37m
    $288–616

  5. Bus to Felipe Ángeles International Airport, fly

    1. Take the bus from Puebla Terminal CAPU to Terminal Central de Autobuses del Nortebus bus
    2. Fly from Felipe Ángeles International Airport (NLU) to Tocumen International Airport (PTY)plane plane NLU - PTY
    12h 11m
    $370–1,027

  6. Bus

    1. Take the bus from Puebla to Tapachulabus bus
    2. Take the bus from Tapachula to San Salvadorbus bus
    3. Take the bus from Terminal San Carlos - CCA to Terminal Atlántico Nortebus bus Sac
    4. Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus bus
    2d 15h
    $203–293

Hermanos Serdán International Airport (PBC) to Tocumen International Airport (PTY) flights

Calendar25Weekly Planes
Duration7h 9mAverage Duration
Ticket$147Cheapest Price
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Questions & Answers

Map of how to get from Puebla to Panama City.ExpandLaunch map view
  • Distance: 2,383.2 km
  • Duration: 9h 33m

What companies run services between Puebla, Mexico and Panama City, Panama?

Volaris, Copa Airlines, and Viva Aerobus fly from Hermanos Serdán International Airport (PBC) to Tocumen International Airport (PTY) 4 times a day. Alternatively, you can take a bus from Puebla to Terminal Tica Bus Panamá via San Cristóbal de las Casas, San Cristóbal de las Casas, Panajachel, San Salvador, San José, and Terminal Tica Bus San José in around 2d 15h.

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