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How to get fromPueblo to Knoxvilleby bus, plane, train, bus (Greyhound, Flixbus), or car

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There are 10 ways to get from Pueblo to Knoxville by bus, plane, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Denver, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Fly from Denver (DEN) to Mcghee Tyson Airport (TYS)plane plane DEN - TYS
    7h 2m
    $323–1,301

  2. Bus to Denver, fly to Asheville Regional Airport, drive

    cheapest
    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Fly from Denver (DEN) to Asheville Regional Airport (AVL)plane plane DEN - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    9h 14m
    $138–541

  3. Bus, train

    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Take the train from Denver to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 8h
    $1,251–2,034

  4. Bus

    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 10h
    $531–804

  5. Drive  1,270.2 mi

    1. Drive from Pueblo to Knoxvillecar car 1,270.2 mi
    22h 43m
    $218–314

  6. Bus to Colorado Springs Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Pueblo, CO to Colorado Springsbus bus
    2. Fly from Colorado Springs Airport (COS) to Mcghee Tyson Airport (TYS)plane plane COS - TYS
    8h 8m
    $370–1,426

  7. Fly Pueblo Memorial Airport to Mcghee Tyson Airport

    1. Fly from Pueblo Memorial Airport (PUB) to Mcghee Tyson Airport (TYS)plane plane PUB - TYS
    5h 23m
    $373–1,427

  8. Bus to Denver, fly to Nashville, drive

    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Fly from Denver (DEN) to Nashville (BNA)plane plane DEN - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    9h 24m
    $227–626

  9. Drive to San Luis Valley Regional Airport, fly to Mcghee Tyson Airport

    1. Drive from Pueblo to San Luis Valley Regional Airport (ALS)car car
    2. Fly from San Luis Valley Regional Airport (ALS) to Mcghee Tyson Airport (TYS)plane plane ALS - TYS
    7h 42m
    $356–1,400

  10. Bus, train via Ossining

    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Take the train from Denver to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 9h
    $1,216–1,911

Denver (DEN) to Mcghee Tyson Airport (TYS) flights

Calendar73Weekly Planes
Duration4h 27mAverage Duration
Ticket$252Cheapest Price
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Comparing Your Travel Options

Map of how to get from Pueblo to Knoxville.ExpandLaunch map view
  • Distance: 1,309.8 mi
  • Duration: 7h 2m

What companies run services between Pueblo, CO, USA and Knoxville, TN, USA?

You can take a bus from Pueblo Transit to Knoxville via Denver Union Station, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 2d 10h. Alternatively, Key Lime, United Airlines, and two other airlines fly from Pueblo Memorial Airport (PUB) to Mcghee Tyson Airport (TYS) twice daily.

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