Rome2Rio

How to get fromPueblo to Knoxvilleby bus, plane, bus (Greyhound, Flixbus), train, car, or bus (Greyhound)

Find Transport to Knoxville

See all options

There are 12 ways to get from Pueblo to Knoxville by bus, plane, bus (Greyhound, Flixbus), train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Colorado Springs Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Pueblo, CO to Colorado Springs, CObus bus
    2. Fly from Colorado Springs Airport (COS) to Mcghee Tyson Airport (TYS)plane plane COS - TYS
    8h 2m
    $284–1,009

  2. Bus to Denver, fly to Asheville Regional Airport, drive

    cheapest
    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Fly from Denver (DEN) to Asheville Regional Airport (AVL)plane plane DEN - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    9h 23m
    $160–579

  3. Bus via Indianapolis

    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Take the bus from Denver to Indianapolisbus bus
    3. Take the bus from Indianapolis to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 7h

  4. Bus, train via Farragut

    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Take the train from Denver to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 8h
    $841–1,637

  5. Drive 1,270.2 mi

    1. Drive from Pueblo to Knoxvillecar car 1,270.2 mi
    22h 43m
    $232–335

  6. Bus to Denver, fly to Mcghee Tyson Airport

    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Fly from Denver (DEN) to Mcghee Tyson Airport (TYS)plane plane DEN - TYS
    7h 17m
    $323–964

  7. Fly Pueblo Memorial Airport to Mcghee Tyson Airport

    1. Fly from Pueblo Memorial Airport (PUB) to Mcghee Tyson Airport (TYS)plane plane PUB - TYS
    5h 19m
    $313–1,077

  8. Bus to Denver, fly to Nashville, drive

    1. Take the bus from Pueblo Transit to Denver Union Stationbus bus
    2. Fly from Denver (DEN) to Nashville (BNA)plane plane DEN - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    9h 34m
    $238–694

  9. Drive to San Luis Valley Regional Airport, fly to Mcghee Tyson Airport

    1. Drive from Pueblo to San Luis Valley Regional Airport (ALS)car car
    2. Fly from San Luis Valley Regional Airport (ALS) to Mcghee Tyson Airport (TYS)plane plane ALS - TYS
    8h 9m
    $267–952

  10. Bus to Colorado Springs Airport, fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Take the bus from Pueblo, CO to Colorado Springs, CObus bus
    2. Fly from Colorado Springs Airport (COS) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane COS - ATL
    3. Drive from Atlanta-Airport-ATL to Knoxvillecar car
    9h 39m
    $204–749

  11. Bus, train

    1. Take the bus from Pueblo, CO to Denverbus bus
    2. Take the train from Denver to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 9h
    $830–1,577

  12. Bus

    1. Take the bus from Pueblo, CO to Colorado Springsbus bus
    2. Take the bus from Colorado Springs Downtown Station to Union Stationbus bus
    3. Take the bus from Denver Union Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    5. Take the bus from New York to Knoxvillebus bus Nyc
    2d 12h
    $525–901

Colorado Springs Airport (COS) to Mcghee Tyson Airport (TYS) flights

Calendar85Weekly Planes
Duration6h 19mAverage Duration
Ticket$206Cheapest Price
See schedules

Questions & Answers

Map of how to get from Pueblo to Knoxville.ExpandLaunch map view
  • Distance: 1,221 mi
  • Duration: 8h 2m

What companies run services between Pueblo, CO, USA and Knoxville, TN, USA?

You can take a bus from Pueblo Transit to Knoxville via Denver Union Station, Denver, Indianapolis, Indianapolis, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 2d 7h. Alternatively, Key Lime, United Airlines, and Southwest Airlines fly from Pueblo Memorial Airport (PUB) to Mcghee Tyson Airport (TYS) twice daily.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers