There are 4 ways to get from Puerto Rico to Santiago de Cuba by plane or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Eugenio María De Hostos Airport to Antonio Maceo International Airport
best- Fly from Eugenio María De Hostos Airport (MAZ) to Antonio Maceo International Airport (SCU)plane MAZ - SCU
18h 34m$99–424Fly Aguadilla to Antonio Maceo International Airport
- Fly from Aguadilla (BQN) to Antonio Maceo International Airport (SCU)plane BQN - SCU
11h 33m$147–659Fly Luis Munoz Marin International Airport to Frank País International Airport, bus
- Fly from Luis Munoz Marin International Airport (SJU) to Frank País International Airport (HOG)plane SJU - HOG
- Take the bus from Holguin Airport to Terminal de Ómnibus Nacionales Santiago de Cubabus
13h 47m$170–557Fly Ponce to Antonio Maceo International Airport
- Fly from Ponce (PSE) to Antonio Maceo International Airport (SCU)plane PSE - SCU
12h 50m$144–654
Eugenio María De Hostos Airport (MAZ) to Antonio Maceo International Airport (SCU) flights
Comparing Your Travel Options
The cheapest way to get from Puerto Rico to Santiago de Cuba is to fly which costs $95 - $430 and takes 18h 34m.
The fastest way to get from Puerto Rico to Santiago de Cuba is to fly which takes 11h 33m and costs $140 - $700.
The distance between Puerto Rico and Santiago de Cuba is 947 km.
It takes approximately 18h 34m to get from Puerto Rico to Santiago de Cuba, including transfers.
What companies run services between Puerto Rico and Santiago de Cuba?
Cape Air, American Airlines, and three other airlines fly from Eugenio María De Hostos Airport (MAZ) to Antonio Maceo International Airport (SCU) twice daily.
- Website
- aa.com
Flights from Eugenio María De Hostos Airport to Antonio Maceo International Airport via Luis Munoz Marin International Airport, Miami
- Ave. Duration
- 19h 17m
- When
- Wednesday to Sunday
- Estimated price
- $95–420
Flights from Aguadilla to Antonio Maceo International Airport via Orlando, Miami
- Ave. Duration
- 13h 36m
- When
- Wednesday to Sunday
- Estimated price
- $140–650
Flights from Luis Munoz Marin International Airport to Frank País International Airport via Miami
- Ave. Duration
- 7h 50m
- When
- Every day
- Estimated price
- $100–460
- Website
- flyallways.com
Flights from Aguadilla to Antonio Maceo International Airport via Fort Lauderdale, Kingston
- Ave. Duration
- 10h 14m
- When
- Monday
- Estimated price
- $140–650
Flights from Ponce to Antonio Maceo International Airport via Fort Lauderdale, Kingston
- Ave. Duration
- 11h 55m
- When
- Monday
- Estimated price
- $140–650
- Website
- skyhighdominicana.com
Flights from Eugenio María De Hostos Airport to Antonio Maceo International Airport via Luis Munoz Marin International Airport, Santo Domingo
- Ave. Duration
- 20h 26m
- When
- Tuesday
- Estimated price
- $350–900
- Website
- intercaribbean.com
Flights from Aguadilla to Antonio Maceo International Airport via New York JFK, Kingston
- Ave. Duration
- 13h 45m
- When
- Wednesday
- Estimated price
- $240–950
- Phone
- +53 59 89 0616
- [email protected]
- Website
- Viazul
Bus from Holguin Airport to Terminal de Ómnibus Nacionales Santiago de Cuba
- Ave. Duration
- 2h 47m
- Frequency
- 5 times a day
- Estimated price
- $15–22
- Website
- Viazul
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