There are 12 ways to get from Quakertown to Buffalo by train, plane, bus, bus (Flixbus), car, bus (Greyhound), or train (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Philadelphia International Airport, fly to Buffalo Niagara International Airport
best- Take the train from Doylestown to Suburban Stationtrain
- Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane PHL - BUF
6h 36m$175–896Drive 308.6 mi
cheapest- Drive from Quakertown to Buffalocar 308.6 mi
6h 27m$53–77Bus, train
- Take the bus from Quakertown, PA - 60 4th St to New York, NYbus Doylestown-Flemington Eastbound
- Take the train from New York Penn Station to Buffalotrain VIA Rail
12h 33m$181–356Bus via New York
- Take the bus from Quakertown, PA - 60 4th St to New York, NYbus Doylestown-Flemington Eastbound
- Take the bus from New York Midtown to Buffalobus FlixBus 2686 / ...
12h 41m$141–186Bus to Laguardia Airport, fly to Buffalo Niagara International Airport
- Take the bus from Quakertown, PA - 60 4th St to New York, NYbus
- Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane LGA - BUF
7h 12m$179–807Bus to John F. Kennedy International Airport, fly to Buffalo Niagara International Airport
- Take the bus from Quakertown, PA - 60 4th St to New York, NYbus
- Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane JFK - BUF
7h 16m$155–563Train to Philadelphia International Airport, fly to Rochester, bus
- Take the train from Doylestown to Suburban Stationtrain
- Fly from Philadelphia International Airport (PHL) to Rochester (ROC)plane PHL - ROC
- Take the bus from Rochester Bus Stop to Buffalobus
7h 48m$230–1,110Train, train to Baltimore-Washington International Airport, fly to Buffalo Niagara International Airport
- Take the train from Doylestown to Jefferson Stationtrain
- Take the train from 30th Street Station to BWI Thurgood Marshalltrain
- Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane BWI - BUF
7h 43m$179–1,346Train, train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport
- Take the train from Doylestown to Jefferson Stationtrain
- Take the train from 30th Street Station to Newark Liberty International Airporttrain
- Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane EWR - BUF
8h 10m$185–716Bus
- Take the bus from Quakertown, PA - 60 4th St to New York, NYbus Doylestown-Flemington Eastbound
- Take the bus from Port Authority Bus Terminal to Buffalobus Greyhound US0215 / ...
12h 45m$126–326Bus, train via New York
- Take the bus from Quakertown, PA - 60 4th St to New York, NYbus Doylestown-Flemington Eastbound
- Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain Empire Service / ...
12h 51m$311–446Train
- Take the train from Doylestown to Jefferson Stationtrain Lan
- Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain
- Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain
13h 46m$320–1,038
Quakertown to Buffalo by bus, foot, and train
Comparing Your Travel Options
The cheapest way to get from Quakertown to Buffalo is to drive which costs $50 - $80 and takes 6h 27m.
The fastest way to get from Quakertown to Buffalo is to drive which takes 6h 27m and costs $50 - $80.
No, there is no direct bus from Quakertown to Buffalo. However, there are services departing from Quakertown, PA - 60 4th St and arriving at Buffalo via New York Midtown. The journey, including transfers, takes approximately 12h 41m.
No, there is no direct train from Quakertown to Buffalo. However, there are services departing from Doylestown and arriving at Buffalo via 11th St, 30th Street Station and Ny Moynihan Train Hall At Penn Station. The journey, including transfers, takes approximately 13h 46m.
The distance between Quakertown and Buffalo is 349 miles. The road distance is 310.4 miles.
The best way to get from Quakertown to Buffalo without a car is to bus and train which takes 12h 33m and costs $180 - $360.
It takes approximately 6h 36m to get from Quakertown to Buffalo, including transfers.
Quakertown to Buffalo bus services, operated by Trans-bridge Lines, depart from Quakertown, PA - 60 4th St station.
Quakertown to Buffalo train services, operated by SEPTA, depart from Doylestown station.
The best way to get from Quakertown to Buffalo is to bus via New York which takes 12h 41m and costs $140 - $190. Alternatively, you can train, which costs $320 - $1,100 and takes 13h 46m.
What companies run services between Quakertown, PA, USA and Buffalo, NY, USA?
You can take a bus from Quakertown, PA - 60 4th St to Buffalo via New York, NY and New York Midtown in around 12h 41m. Alternatively, you can take a bus from Quakertown, PA - 60 4th St to Buffalo via Doylestown, PA - Septa Train Station Bus Shelter - 130 S Clinton Ave, Doylestown, Jefferson Station, 11th St, Drexel Station at 30th St, 30th Street Station, and Ny Moynihan Train Hall At Penn Station in around 13h 46m.
- Website
- delta.com
Flights from Laguardia Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $100–700
Flights from John F. Kennedy International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $65–440
- Website
- united.com
Flights from Philadelphia International Airport to Buffalo Niagara International Airport via Washington Dulles
- Ave. Duration
- 3h 43m
- When
- Every day
- Estimated price
- $130–850
Flights from Philadelphia International Airport to Rochester via Washington Dulles
- Ave. Duration
- 3h 50m
- When
- Tuesday, Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–1,100
Flights from Newark Liberty International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $80–550
Flights from Newark Liberty International Airport to Buffalo Niagara International Airport via Washington Dulles
- Ave. Duration
- 3h 50m
- When
- Every day
- Estimated price
- $100–600
- Website
- aa.com
Flights from Philadelphia International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $110–800
Flights from Laguardia Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $100–700
Flights from Philadelphia International Airport to Rochester
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $140–1,000
- Website
- southwest.com
Flights from Baltimore-Washington International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 18m
- When
- Every day
- Estimated price
- $90–600
- Website
- jetblue.com
Flights from John F. Kennedy International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $65–440
- Phone
- +1 215-580-7800
- Website
- SEPTA
Train from Doylestown to Suburban Station
- Ave. Duration
- 1h 27m
- Frequency
- Hourly
- Estimated price
- $3–5
- Website
- SEPTA
- Schedules at
- SEPTA: World Cup 2026
Train from Doylestown to Suburban Station
- Ave. Duration
- 1h 27m
- Frequency
- Hourly
- Estimated price
- $3–5
- Website
- SEPTA
- Schedules at
- SEPTA: World Cup 2026
Train from Doylestown to Jefferson Station
- Ave. Duration
- 1h 22m
- Frequency
- Hourly
- Estimated price
- $3–5
- Website
- SEPTA
- Schedules at
- SEPTA: World Cup 2026
Train from Doylestown to Jefferson Station
- Ave. Duration
- 1h 22m
- Frequency
- Hourly
- Estimated price
- $3–5
- Website
- SEPTA
- Schedules at
- SEPTA: World Cup 2026
Train from Doylestown to Jefferson Station
- Ave. Duration
- 1h 22m
- Frequency
- Hourly
- Estimated price
- $3–5
- Website
- SEPTA
- Schedules at
- SEPTA: World Cup 2026
- Phone
- +1 888 842-7245
- Website
- VIA Rail
Train from New York Penn Station to Buffalo
- Ave. Duration
- 8h 14m
- Frequency
- Once daily
- Estimated price
- $110–280
- Website
- VIA Rail
- Escape
- $110–260
- Business
- $150–270
- Business Plus
- $160–280
- Economy
- $130–270
- Economy Plus
- $140–270
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from 30th Street Station to BWI Thurgood Marshall
- Ave. Duration
- 1h 25m
- Frequency
- Hourly
- Estimated price
- $55–90
- Website
- Amtrak
Train from 30th Street Station to Newark Liberty International Airport
- Ave. Duration
- 56 min
- Frequency
- Every 3 hours
- Estimated price
- $40–70
- Website
- Amtrak
Train from Ny Moynihan Train Hall At Penn Station to Buffalo
- Ave. Duration
- 8h 35m
- Frequency
- 3 times a day
- Estimated price
- $240–370
- Website
- Amtrak
Train from 30th Street Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 1h 24m
- Frequency
- Every 30 minutes
- Estimated price
- $45–80
- Website
- Amtrak
Train from Ny Moynihan Train Hall At Penn Station to Buffalo
- Ave. Duration
- 8h 35m
- Frequency
- 3 times a day
- Estimated price
- $240–370
- Website
- Amtrak
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from 30th Street Station to BWI Thurgood Marshall
- Ave. Duration
- 1h 22m
- Frequency
- 5 times a day
- Estimated price
- $24–650
- Schedules at
- Amtrak Acela
- Website
- Amtrak
- Business Class
- $24–460
- First Class
- $140–650
Train from 30th Street Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- $20–600
- Schedules at
- Amtrak Acela
- Website
- Amtrak
- Business Class
- $20–460
- First Class
- $130–600
- Phone
- +1 610-868-6001
- [email protected]
- Website
- transbridgelines.com
Bus from Quakertown, PA - 60 4th St to New York, NY
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a week
- Estimated price
- $70–80
- Schedules at
- transbridgelines.com
- Adult
- $70–80
Bus from Quakertown, PA - 60 4th St to New York, NY
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a week
- Estimated price
- $70–80
- Schedules at
- transbridgelines.com
- Adult
- $70–80
Bus from Quakertown, PA - 60 4th St to New York, NY
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a week
- Estimated price
- $70–80
- Schedules at
- transbridgelines.com
- Adult
- $70–80
Bus from Quakertown, PA - 60 4th St to New York, NY
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a week
- Estimated price
- $70–80
- Schedules at
- transbridgelines.com
- Adult
- $70–80
Bus from Quakertown, PA - 60 4th St to New York, NY
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a week
- Estimated price
- $70–80
- Schedules at
- transbridgelines.com
- Adult
- $70–80
Bus from Quakertown, PA - 60 4th St to New York, NY
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a week
- Estimated price
- $70–80
- Schedules at
- transbridgelines.com
- Adult
- $70–80
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from New York Midtown to Buffalo
- Ave. Duration
- 8h 35m
- Frequency
- Hourly
- Estimated price
- $70–110
- Schedules at
- Flixbus USA
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- $12–18
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 20m
- Frequency
- Every 3 hours
- Estimated price
- $13–20
- Website
- Greyhound
Bus from Port Authority Bus Terminal to Buffalo
- Ave. Duration
- 8h 40m
- Frequency
- Every 3 hours
- Estimated price
- $75–120
- Website
- Greyhound
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Port Authority Bus Terminal to Buffalo
- Saver
- $55–240
- Flexible
- $100–250
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Booking & Getting There
Quakertown to Buffalo bus services, operated by Trans-bridge Lines, arrive at New York, NY station.
Quakertown to Buffalo train services, operated by SEPTA, arrive at Jefferson Station.
Yes, the driving distance between Quakertown to Buffalo is 310 miles. It takes approximately 6h 27m to drive from Quakertown to Buffalo.
There are 254+ hotels available in Buffalo.

























