There are 4 ways to get from Quito to Santa Cruz by car, plane, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Car, fly
best- Drive from Quito to Quito Airportcar
- Fly from Mariscal Sucre International Airport (UIO) to Viru Viru International Airport (VVI)plane UIO - VVI
9h 35m$486–776Bus
cheapest- Take the bus from Terminal Terrestre Quitumbe to Lima Javier Pradobus
- Take the bus from Lima - Terminal Arriola to La Pazbus
- Take the bus from La Paz to Santa Cruzbus
3d 12h$166–714Bus via Lima
- Take the bus from Terminal Terrestre Quitumbe to Gran Terminal Terrestre Plaza Nortebus
- Take the bus from Oltursa Lima Terminal to La Pazbus
- Take the bus from La Paz to Santa Cruzbus
3d 2h$261–352Drive 4,012.2 km
- Drive from Quito to Santa Cruz de la Sierracar 4,012.2 km
2d 9h$228–329
Mariscal Sucre International Airport (UIO) to Viru Viru International Airport (VVI) flights
Comparing Your Travel Options
The cheapest way to get from Quito to Santa Cruz is to drive which costs $220 - $330 and takes 2 days 9h.
The fastest way to get from Quito to Santa Cruz is to car and fly which takes 9h 35m and costs $480 - $800.
No, there is no direct bus from Quito to Santa Cruz. However, there are services departing from Terminal Terrestre Quitumbe and arriving at Santa Cruz via Gran Terminal Terrestre Plaza Norte, Oltursa Lima Terminal and La Paz. The journey, including transfers, takes approximately 3 days 2h.
The distance between Quito and Santa Cruz is 2623 km. The road distance is 4012.2 km.
The best way to get from Quito to Santa Cruz without a car is to bus via Lima which takes 3 days 2h and costs $260 - $360.
It takes approximately 9h 35m to get from Quito to Santa Cruz, including transfers.
Quito to Santa Cruz bus services, operated by Lineas de Los Andes, depart from Terminal Terrestre Quitumbe station.
Quito to Santa Cruz bus services, operated by Lineas de Los Andes, arrive at Gran Terminal Terrestre Plaza Norte station.
Santa Cruz is 1h ahead of Quito. It is currently 12:46 PM in Quito and 1:46 PM in Santa Cruz.
Yes, the driving distance between Quito to Santa Cruz is 4012 km. It takes approximately 2 days 9h to drive from Quito to Santa Cruz.
What companies run services between Quito, Ecuador and Santa Cruz, Bolivia?
You can take a bus from Terminal Terrestre Quitumbe to Santa Cruz de la Sierra via Gran Terminal Terrestre Plaza Norte, Oltursa Lima Terminal, La Paz, and Santa Cruz in around 3d 2h.
- Website
- avianca.com
Flights from Mariscal Sucre International Airport to Viru Viru International Airport via Bogota
- Ave. Duration
- 6h 50m
- When
- Every day
- Estimated price
- $310–1,200
Flights from Mariscal Sucre International Airport to Viru Viru International Airport via Medellin Jose Marie Cordova, Bogota
- Ave. Duration
- 8h 10m
- When
- Every day
- Estimated price
- $320–1,200
- Phone
- +51 9 6788 4526
- [email protected]
- Website
- Lineas De Los Andes
Bus from Terminal Terrestre Quitumbe to Gran Terminal Terrestre Plaza Norte
- Ave. Duration
- 23h 58m
- Frequency
- Once daily
- Estimated price
- $120–150
- Website
- Lineas De Los Andes
- Phone
- +593 98 414 6312
- [email protected]
- Website
- Fantasy Travel Ecuador
Car from Quito to Quito Airport
- Ave. Duration
- 20 min
- Frequency
- On demand
- Estimated price
- $25
- Schedules at
- Fantasy Travel Ecuador
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Booking & Getting There
There are 742+ hotels available in Santa Cruz.



