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How to get fromRaleigh to Mayo Clinicby plane, bus (Greyhound, Flixbus), train, bus, or car

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There are 7 ways to get from Raleigh to Mayo Clinic by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Raleigh-Durham International Airport to Rochester

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Rochester (RST)plane plane RDU - RST
    7h 33m
    $102–482

  2. Bus

    1. Take the bus from Raleigh Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    32h 57m
    $235–428

  3. Train, bus via Madison

    1. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    34h 12m
    $423–827

  4. Drive 1,135.1 mi

    1. Drive from Raleigh to Mayo Cliniccar car 1,135.1 mi
    19h 39m
    $208–300

  5. Fly Raleigh-Durham International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Raleigh-Durham International Airport (RDU) to Minneapolis–Saint Paul International Airport (MSP)plane plane RDU - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 16m
    $174–904

  6. Train to Piedmont Triad International Airport, fly to Rochester

    1. Take the train from Raleigh Union Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Rochester (RST)plane plane GSO - RST
    8h 52m
    $166–692

  7. Train, bus

    1. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    35h 37m
    $506–1,007

Raleigh to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration35h 37mAverage Duration
Ticket$506Cheapest Price
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Questions & Answers

Map of how to get from Raleigh to Mayo Clinic.ExpandLaunch map view
  • Distance: 934.9 mi
  • Duration: 7h 33m

What companies run services between Raleigh, NC, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from Raleigh-Durham International Airport (RDU) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from GoRaleigh Station to Mayo Clinic via Capital Blvd at Crabtree Blvd, Raleigh Bus Station, Washington Union Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 32h 57m.

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