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How to get fromRoanoke to Des Moinesby plane, bus (Greyhound, Amtrak), train, bus, or car

Find Transport to Des Moines

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There are 7 ways to get from Roanoke to Des Moines by plane, bus (Greyhound, Amtrak), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Roanoke Regional Airport-Woodrum Field

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Des Moines (DSM)plane plane ROA - DSM
    6h 12m
    $102–457

  2. Bus

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    26h
    $183–281

  3. Train, bus

    1. Take the train from Roanoke to Charlottesvilletrain train
    2. Take the train from Charlottesville to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    29h 46m
    $249–534

  4. Drive  935.2 mi

    1. Drive from Roanoke to Des Moinescar car 935.2 mi
    16h 27m
    $171–247

  5. Drive to Greenbrier Valley Airport, fly

    1. Drive from Roanoke to Greenbrier Valley Airport (LWB)car car
    2. Fly from Greenbrier Valley Airport (LWB) to Des Moines (DSM)plane plane LWB - DSM
    6h 59m
    $111–461

  6. Train to Lynchburg Regional Airport, fly

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Fly from Lynchburg Regional Airport (LYH) to Des Moines (DSM)plane plane LYH - DSM
    9h 3m
    $118–485

  7. Train, bus via Chicago

    1. Take the train from Roanoke to Charlottesvilletrain train
    2. Take the train from Charlottesville to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    32h
    $279–609

Roanoke to Des Moines by bus

Calendar7Weekly Buses
Duration26hAverage Duration
Ticket$183Cheapest Price
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Comparing Your Travel Options

Map of how to get from Roanoke to Des Moines.ExpandLaunch map view
  • Distance: 798.3 mi
  • Duration: 6h 12m

What companies run services between Roanoke, VA, USA and Des Moines, IA, USA?

United Airlines, Delta, and American Airlines fly from Roanoke Regional Airport-Woodrum Field (ROA) to Des Moines (DSM) every 3 hours. Alternatively, you can take a bus from Roanoke Bus Stop to Des Moines via Nashville Bus Station and Indianapolis Union Station in around 26h.

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