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How to get fromRoanoke to Florenceby plane, train, bus, bus (Greyhound, Flixbus), car, or train (Amtrak)

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There are 5 ways to get from Roanoke to Florence by plane, train, bus, bus (Greyhound, Flixbus), car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Florence Regional Airport (FLO)plane plane ROA - FLO
    5h 10m
    $59–317

  2. Drive 240.8 mi

    cheapest
    1. Drive from Roanoke to Florencecar car 240.8 mi
    4h 54m
    $44–64

  3. Train, bus

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Take the train from Lynchburg to High Pointtrain train
    3. Take the bus from High Point Terminal to Fayettevillebus bus
    4. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train
    11h 10m
    $99–209

  4. Bus

    1. Take the bus from Roanoke Bus Stop to Lynchburg Transit Centerbus bus
    2. Take the bus from Lynchburg Transit Center to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    12h 10m
    $62–123

  5. Train (Amtrak)

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Take the train from Lynchburg to Greensborotrain train
    3. Take the train from Greensboro to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    11h 25m
    $127–274

Roanoke to Florence by train and bus

Calendar7Weekly Services
Duration11h 10mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Roanoke to Florence.ExpandLaunch map view
  • Distance: 225.8 mi
  • Duration: 5h 10m

What companies run services between Roanoke, VA, USA and Florence, SC, USA?

American Airlines flies from Roanoke Regional Airport-Woodrum Field (ROA) to Florence Regional Airport (FLO) once daily. Alternatively, you can take a bus from Roanoke Bus Stop to Florence Bus Station via Lynchburg Transit Center, Charlotte Bus Station, and Camden in around 12h 10m.

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