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How to get fromRoanoke to Knoxvilleby bus, taxi, shuttle, car, plane, or train

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There are 5 ways to get from Roanoke to Knoxville by bus, taxi, shuttle, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, taxi, shuttle, drive

    best
    1. Take the bus from 3rd St Station Slip D to Exit 118 - Park and Ridebus bus Swb
    2. Take the bus from Route 460 Park and Ride to Park and Ride Lot at I-81 Exit 5bus bus
    3. Take the taxi from Bristol Exit 5 Park & Ride Lot to Black Bear Resorttaxi taxi
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    8h 34m
    $271–325

  2. Drive 256.5 mi

    cheapest
    1. Drive from Roanoke to Knoxvillecar car 256.5 mi
    4h 18m
    $47–68

  3. Fly from Roanoke Regional Airport-Woodrum Field

    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Mcghee Tyson Airport (TYS)plane plane ROA - TYS
    5h 22m
    $149–624

  4. Bus, taxi, shuttle, drive via Chilhowee at Holston

    1. Take the bus from 3rd St Station Slip D to Exit 118 - Park and Ridebus bus Swb
    2. Take the bus from Route 460 Park and Ride to Park and Ride Lot at I-81 Exit 5bus bus
    3. Take the taxi from Bristol Exit 5 Park & Ride Lot to Black Bear Resorttaxi taxi
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Chilhowee at Holstoncar car
    9h 18m
    $272–326

  5. Train to Lynchburg Regional Airport, fly

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Fly from Lynchburg Regional Airport (LYH) to Mcghee Tyson Airport (TYS)plane plane LYH - TYS
    7h 56m
    $164–706

Roanoke Regional Airport-Woodrum Field (ROA) to Mcghee Tyson Airport (TYS) flights

Calendar94Weekly Planes
Duration4h 43mAverage Duration
Ticket$91Cheapest Price
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Questions & Answers

Map of how to get from Roanoke to Knoxville.ExpandLaunch map view
  • Distance: 322.8 mi
  • Duration: 8h 34m

What companies run services between Roanoke, VA, USA and Knoxville, TN, USA?

American Airlines, Delta, and two other airlines fly from Roanoke Regional Airport-Woodrum Field (ROA) to Mcghee Tyson Airport (TYS) hourly.

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