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How to get fromRoanoke to Louisvilleby plane, bus (Greyhound, Amtrak, Flixbus), train, bus, car, or bus (Greyhound)

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There are 7 ways to get from Roanoke to Louisville by plane, bus (Greyhound, Amtrak, Flixbus), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Roanoke Regional Airport-Woodrum Field to Louisville International Airport

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Louisville International Airport (SDF)plane plane ROA - SDF
    6h 23m
    $100–607

  2. Fly Roanoke Regional Airport-Woodrum Field to Blue Grass Airport, drive

    cheapest
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Blue Grass Airport (LEX)plane plane ROA - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 23m
    $72–373

  3. Bus

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Nashville Bus Station to Louisville Bus Stationbus bus Greyhound US0105 / ...
    12h 20m
    $94–164

  4. Train, bus

    1. Take the train from Roanoke to Charlottesvilletrain train
    2. Take the train from Charlottesville to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    21h 41m
    $212–470

  5. Drive  414.4 mi

    1. Drive from Roanoke to Louisvillecar car 414.4 mi
    7h 18m
    $76–110

  6. Train to Lynchburg Regional Airport, fly to Louisville International Airport

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Fly from Lynchburg Regional Airport (LYH) to Louisville International Airport (SDF)plane plane LYH - SDF
    9h
    $112–635

  7. Bus via Preston @ Vim

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus Memphis
    13h 41m
    $106–179

Roanoke to Louisville by bus

Calendar7Weekly Buses
Duration12h 20mAverage Duration
Ticket$94Cheapest Price
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Questions & Answers

Map of how to get from Roanoke to Louisville.ExpandLaunch map view
  • Distance: 334 mi
  • Duration: 6h 23m

What companies run services between Roanoke, VA, USA and Louisville, KY, USA?

American Airlines, Delta, and United Airlines fly from Roanoke Regional Airport-Woodrum Field (ROA) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Roanoke Bus Stop to Louisville Bus Station via Nashville Bus Station in around 12h 20m.

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