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How to get fromRoanoke to Louisvilleby plane, bus (Greyhound, Amtrak), train, bus, car, or bus (Greyhound)

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There are 7 ways to get from Roanoke to Louisville by plane, bus (Greyhound, Amtrak), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Roanoke Regional Airport-Woodrum Field to Louisville International Airport

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Louisville International Airport (SDF)plane plane ROA - SDF
    6h 39m
    $105–657

  2. Fly Roanoke Regional Airport-Woodrum Field to Blue Grass Airport, drive

    cheapest
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Blue Grass Airport (LEX)plane plane ROA - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 25m
    $72–373

  3. Bus

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Nashville to Louisville, KYbus bus Nashville
    12h 50m
    $100–159

  4. Train, bus (Amtrak)

    1. Take the train from Roanoke to Charlottesvilletrain train
    2. Take the train from Charlottesville to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    21h 46m
    $213–553

  5. Drive  414.4 mi

    1. Drive from Roanoke to Louisvillecar car 414.4 mi
    7h 18m
    $76–110

  6. Train to Lynchburg Regional Airport, fly to Louisville International Airport

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Fly from Lynchburg Regional Airport (LYH) to Louisville International Airport (SDF)plane plane LYH - SDF
    9h 3m
    $117–691

  7. Bus via Preston @ Vim

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus Memphis
    13h 41m
    $108–174

Roanoke to Louisville by bus

Calendar7Weekly Buses
Duration12h 50mAverage Duration
Ticket$100Cheapest Price
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Comparing Your Travel Options

Map of how to get from Roanoke to Louisville.ExpandLaunch map view
  • Distance: 334 mi
  • Duration: 6h 39m

What companies run services between Roanoke, VA, USA and Louisville, KY, USA?

Delta, American Airlines, and United Airlines fly from Roanoke Regional Airport-Woodrum Field (ROA) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Roanoke Bus Stop to Louisville, KY via Nashville in around 12h 50m.

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