Rome2Rio

How to get fromRoanoke to Mechanicsburgby train, bus, bus (Greyhound), car, plane, or train (Amtrak)

Find Transport to Mechanicsburg

See all options

There are 7 ways to get from Roanoke to Mechanicsburg by train, bus, bus (Greyhound), car, plane, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Roanoke to Washington Union Stationtrain train Northeast Regional
    2. Take the bus from Washington Union Station to Harrisburg Bus Stationbus bus Greyhound US0430
    10h 19m
    $91–185

  2. Drive 279.1 mi

    cheapest
    1. Drive from Roanoke to Mechanicsburgcar car 279.1 mi
    4h 50m
    $51–74

  3. Bus (Greyhound)

    1. Take the bus from Roanoke Bus Stop to Baltimore Downtown Bus Stationbus bus Greyhound US0600
    2. Take the bus from Baltimore Downtown Bus Station to Harrisburg Bus Stationbus bus Greyhound US0430
    10h 59m
    $54–104

  4. Fly to Harrisburg International Airport

    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Harrisburg International Airport (MDT)plane plane ROA - MDT
    6h 21m
    $51–308

  5. Train (Amtrak)

    1. Take the train from Roanoke to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to 30th Street Stationtrain train
    3. Take the train from 30th Street Station to Harrisburgtrain train
    10h 59m
    $144–310

  6. Bus via Washington

    1. Take the bus from Salem VDOT Park & Ride to Washington Union Stationbus bus Highlands Rhythm
    2. Take the bus from Washington Union Station to Harrisburg Bus Stationbus bus Greyhound US0430
    11h 39m
    $55–91

  7. Fly to Philadelphia International Airport, train

    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Philadelphia International Airport (PHL)plane plane ROA - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    7h 34m
    $103–499

Roanoke to Mechanicsburg by train, bus, and foot

Calendar7Weekly Services
Duration10h 19mAverage Duration
Ticket$91Cheapest Price
See schedules

Questions & Answers

Map of how to get from Roanoke to Mechanicsburg.ExpandLaunch map view
  • Distance: 346.5 mi
  • Duration: 10h 19m

What companies run services between Roanoke, VA, USA and Mechanicsburg, Cumberland County, PA, USA?

You can take a bus from Roanoke Bus Stop to E Main St & Arch St WB via Baltimore Downtown Bus Station, Harrisburg Bus Station, and Market Square Transfer Center in around 10h 59m. Alternatively, United Airlines, American Airlines, and Delta fly from Roanoke Regional Airport-Woodrum Field (ROA) to Harrisburg International Airport (MDT) every 2 hours.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers