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How to get fromRoanoke to Mississippiby plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or train

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There are 8 ways to get from Roanoke to Mississippi by plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Gulfport-Biloxi Regional Airport

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Gulfport-Biloxi Regional Airport (GPT)plane plane ROA - GPT
    5h 49m
    $105–508

  2. Bus

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Jacksonbus bus
    17h 25m
    $128–217

  3. Train (Amtrak)

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Take the train from Lynchburg to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Jacksontrain train
    30h 49m
    $309–740

  4. Drive  747.8 mi

    1. Drive from Roanoke to Jacksoncar car 747.8 mi
    12h 19m
    $137–198

  5. Fly to Memphis

    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Memphis (MEM)plane plane ROA - MEM
    5h 26m
    $156–781

  6. Fly to Jackson/Vicksburg

    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Jackson/Vicksburg (JAN)plane plane ROA - JAN
    5h 32m
    $119–454

  7. Fly to Mobile Regional Airport, bus

    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Mobile Regional Airport (MOB)plane plane ROA - MOB
    2. Take the bus from Mobile Bus Station to Biloxi Transit Centerbus bus
    8h 6m
    $107–438

  8. Train, bus

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Take the bus from Lynchburg Transit Center to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Atlanta Downtownbus bus
    4. Take the bus from Atlanta Bus Station to Jacksonbus bus
    21h 33m
    $147–238

Roanoke to Mississippi by bus

Calendar7Weekly Buses
Duration17h 25mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from Roanoke to Mississippi.ExpandLaunch map view
  • Distance: 717 mi
  • Duration: 5h 49m

What companies run services between Roanoke, VA, USA and Mississippi, USA?

American Airlines and Delta fly from Roanoke Regional Airport-Woodrum Field (ROA) to Gulfport-Biloxi Regional Airport (GPT) 5 times a day. Alternatively, you can take a bus from Roanoke Bus Stop to Jackson via Nashville Bus Station and Memphis Bus Station in around 17h 25m.

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