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How to get fromRoanoke to Mount Pleasantby plane, train (Amtrak), train, bus, or car

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There are 8 ways to get from Roanoke to Mount Pleasant by plane, train (Amtrak), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Roanoke Regional Airport-Woodrum Field

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Charleston International Airport (CHS)plane plane ROA - CHS
    7h 58m
    $58–328

  2. Train (Amtrak)

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Take the train from Lynchburg to Greensborotrain train
    3. Take the train from Greensboro to Selma Stationtrain train
    4. Take the train from Selma Station to Charleston Amtrak Stationtrain train
    13h 20m
    $197–384

  3. Train, bus, drive via Wilmington

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Take the train from Lynchburg to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Raleigh Bus Stationbus bus
    4. Take the bus from Raleigh Bus Station to Wilmington Cape Fear Public Transitbus bus
    5. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    6. Drive from Myrtle Beach Bus Station to S. Pinckney St / Society Rdcar car
    7. Take the bus from S. Pinckney St / Society Rd to East Cooper Medical Centerbus bus
    17h 43m
    $107–218

  4. Drive 355.1 mi

    1. Drive from Roanoke to Mount Pleasantcar car 355.1 mi
    7h 27m
    $65–94

  5. Drive to Greenbrier Valley Airport, fly

    1. Drive from Roanoke to Greenbrier Valley Airport (LWB)car car
    2. Fly from Greenbrier Valley Airport (LWB) to Charleston International Airport (CHS)plane plane LWB - CHS
    10h 11m
    $67–352

  6. Train to Lynchburg Regional Airport, fly

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Fly from Lynchburg Regional Airport (LYH) to Charleston International Airport (CHS)plane plane LYH - CHS
    10h 28m
    $73–370

  7. Bus, drive

    1. Take the bus from Roanoke Bus Stop to Lynchburg Transit Centerbus bus
    2. Take the bus from Lynchburg Transit Center to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Myrtle Beach Bus Stationbus bus
    5. Drive from Myrtle Beach Bus Station to S. Pinckney St / Society Rdcar car
    6. Take the bus from S. Pinckney St / Society Rd to East Cooper Medical Centerbus bus
    18h 35m
    $82–157

  8. Train, bus, drive

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Take the train from Lynchburg to High Pointtrain train
    3. Take the bus from High Point Terminal to Fayettevillebus bus
    4. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    5. Drive from Myrtle Beach Bus Station to S. Pinckney St / Society Rdcar car
    6. Take the bus from S. Pinckney St / Society Rd to Stuart Engals Blvd / Wando Crossing Centerbus bus
    22h 4m
    $139–293

Roanoke Regional Airport-Woodrum Field (ROA) to Charleston International Airport (CHS) flights

Calendar98Weekly Planes
Duration5h 2mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

Map of how to get from Roanoke to Mount Pleasant.ExpandLaunch map view
  • Distance: 335.5 mi
  • Duration: 7h 58m

What companies run services between Roanoke, VA, USA and Mount Pleasant, SC, USA?

American Airlines, Delta, and United Airlines fly from Roanoke Regional Airport-Woodrum Field (ROA) to Charleston International Airport (CHS) hourly. Alternatively, you can take a train from Roanoke to Mount Pleasant via Lynchburg, Greensboro, Selma Station, and Charleston Amtrak Station in around 13h 20m.

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