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How to get fromRoanoke to Santa Anaby plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, train, or bus

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There are 6 ways to get from Roanoke to Santa Ana by plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to John Wayne Airport Orange County (SNA)plane plane ROA - SNA
    9h 46m
    $253–889

  2. Fly to Los Angeles International Airport, train

    cheapest
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Los Angeles International Airport (LAX)plane plane ROA - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    11h 7m
    $152–590

  3. Bus

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    4. Take the bus from Los Angeles to Santa Anabus bus
    2d 11h
    $431–842

  4. Train (Amtrak)

    1. Take the train from Roanoke to Charlottesvilletrain train
    2. Take the train from Charlottesville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    2d 20h
    $1,003–2,133

  5. Drive 2,424.7 mi

    1. Drive from Roanoke to Santa Anacar car 2,424.7 mi
    38h 19m
    $443–640

  6. Bus, train

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    4. Take the train from St. Louis to Pomona Amtraktrain train
    3d 5h
    $867–1,841

Roanoke to Santa Ana by bus and foot

Calendar7Weekly Services
Duration2d 11hAverage Duration
Ticket$431Cheapest Price
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Questions & Answers

Map of how to get from Roanoke to Santa Ana.ExpandLaunch map view
  • Distance: 2,144.7 mi
  • Duration: 9h 46m

What companies run services between Roanoke, VA, USA and Santa Ana, CA, USA?

United Airlines, American Airlines, and Delta fly from Roanoke Regional Airport-Woodrum Field (ROA) to John Wayne Airport Orange County (SNA) every 3 hours. Alternatively, you can take a bus from Roanoke Bus Stop to Santa Ana via Nashville Bus Station, St Louis Bus Station, Los Angeles Union Station, and Los Angeles in around 2d 11h.

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