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How to get fromRoanoke to St. Louisby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Greyhound, Flixbus, Amtrak)

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There are 7 ways to get from Roanoke to St. Louis by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Greyhound, Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Roanoke Regional Airport-Woodrum Field

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Lambert–St. Louis International Airport (STL)plane plane ROA - STL
    6h 27m
    $107–557

  2. Bus

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus Greyhound US0186 / ...
    15h 50m
    $109–210

  3. Train (Amtrak)

    1. Take the train from Roanoke to Charlottesvilletrain train
    2. Take the train from Charlottesville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    30h 7m
    $343–801

  4. Drive 672.9 mi

    1. Drive from Roanoke to St. Louiscar car 672.9 mi
    11h 38m
    $123–178

  5. Drive to Greenbrier Valley Airport, fly

    1. Drive from Roanoke to Greenbrier Valley Airport (LWB)car car
    2. Fly from Greenbrier Valley Airport (LWB) to Lambert–St. Louis International Airport (STL)plane plane LWB - STL
    8h 44m
    $116–571

  6. Train to Lynchburg Regional Airport, fly

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Fly from Lynchburg Regional Airport (LYH) to Lambert–St. Louis International Airport (STL)plane plane LYH - STL
    9h 7m
    $120–588

  7. Bus via Carbondale

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    16h 5m
    $108–215

Roanoke to St. Louis by bus

Calendar7Weekly Buses
Duration15h 50mAverage Duration
Ticket$109Cheapest Price
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Questions & Answers

Map of how to get from Roanoke to St. Louis.ExpandLaunch map view
  • Distance: 594.8 mi
  • Duration: 6h 27m

What companies run services between Roanoke, VA, USA and St. Louis, MO, USA?

Delta, United Airlines, and American Airlines fly from Roanoke Regional Airport-Woodrum Field (ROA) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Roanoke Bus Stop to St Louis Bus Station via Nashville Bus Station in around 15h 50m.

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