Rome2Rio

How to get fromRoanoke to St. Louisby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Greyhound, Flixbus, Amtrak)

Find Transport to St. Louis

See all options

There are 7 ways to get from Roanoke to St. Louis by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Greyhound, Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Roanoke Regional Airport-Woodrum Field

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Lambert–St. Louis International Airport (STL)plane plane ROA - STL
    6h 27m
    $117–607

  2. Bus via Carbondale

    cheapest
    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    16h
    $112–230

  3. Bus

    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus Greyhound US0186 / ...
    15h 45m
    $113–220

  4. Train (Amtrak)

    1. Take the train from Roanoke to Charlottesvilletrain train
    2. Take the train from Charlottesville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    30h 7m
    $387–813

  5. Drive 672.9 mi

    1. Drive from Roanoke to St. Louiscar car 672.9 mi
    11h 38m
    $123–178

  6. Drive to Greenbrier Valley Airport, fly

    1. Drive from Roanoke to Greenbrier Valley Airport (LWB)car car
    2. Fly from Greenbrier Valley Airport (LWB) to Lambert–St. Louis International Airport (STL)plane plane LWB - STL
    8h 44m
    $126–621

  7. Train to Lynchburg Regional Airport, fly

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Fly from Lynchburg Regional Airport (LYH) to Lambert–St. Louis International Airport (STL)plane plane LYH - STL
    9h 7m
    $132–639

Roanoke to St. Louis by bus

Calendar7Weekly Buses
Duration15h 45mAverage Duration
Ticket$113Cheapest Price
See schedules

Questions & Answers

Map of how to get from Roanoke to St. Louis.ExpandLaunch map view
  • Distance: 594.8 mi
  • Duration: 6h 27m

What companies run services between Roanoke, VA, USA and St. Louis, MO, USA?

Delta, United Airlines, and American Airlines fly from Roanoke Regional Airport-Woodrum Field (ROA) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a bus from Roanoke Bus Stop to St Louis Bus Station via Nashville Bus Station in around 15h 45m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers