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How to get fromRochester Airport (ROC) to Mayo Clinicby plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 8 ways to get from Rochester Airport (ROC) to Mayo Clinic by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Rochester

    best
    1. Fly from Rochester (ROC) to Rochester (RST)plane plane ROC - RST
    5h 52m
    $123–549

  2. Bus to Buffalo Niagara International Airport, fly to Rochester

    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Rochester (RST)plane plane BUF - RST
    7h 36m
    $158–632

  3. Train, bus via Madison

    1. Take the train from Rochester to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    21h 37m
    $283–542

  4. Bus

    1. Take the bus from Rochester Bus Stop to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    23h 9m
    $192–343

  5. Fly Rochester to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Rochester (ROC) to Minneapolis–Saint Paul International Airport (MSP)plane plane ROC - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 8m
    $189–712

  6. Bus to Buffalo Niagara International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Minneapolis–Saint Paul International Airport (MSP)plane plane BUF - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 22m
    $226–813

  7. Train, bus

    1. Take the train from Rochester to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    23h 1m
    $366–722

  8. Drive 942.9 mi

    1. Drive from Rochester Airport (ROC) to Mayo Cliniccar car 942.9 mi
    15h 54m
    $173–249

Rochester (ROC) to Rochester (RST) flights

Calendar55Weekly Planes
Duration5h 57mAverage Duration
Ticket$109Cheapest Price
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Questions & Answers

Map of how to get from Rochester Airport (ROC) to Mayo Clinic.ExpandLaunch map view
  • Distance: 753.1 mi
  • Duration: 5h 52m

What companies run services between Rochester Airport (ROC), USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines, and Delta fly from Rochester (ROC) to Rochester (RST) every 4 hours. Alternatively, you can take a vehicle from Rochester Airport (ROC) to Mayo Clinic via Rochester Bus Stop, Cleveland Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 23h 9m.

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