Rome2Rio

How to get fromRochester to Knoxvilleby car, plane, bus (Amtrak, Flixbus), train, bus, or bus (Greyhound)

Find Transport to Knoxville

See all options

There are 9 ways to get from Rochester to Knoxville by car, plane, bus (Amtrak, Flixbus), train, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Capital Region International Airport, fly to Mcghee Tyson Airport

    best
    1. Drive from Rochester to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Mcghee Tyson Airport (TYS)plane plane LAN - TYS
    6h 34m
    $210–892

  2. Drive 533.1 mi

    cheapest
    1. Drive from Rochester to Knoxvillecar car 533.1 mi
    9h 2m
    $98–141

  3. Bus via Toledo

    1. Take the bus from Detroit to Toledobus bus
    2. Take the bus from Toledo Bus Stop to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    30h 20m
    $306–456

  4. Drive, train, bus

    1. Drive from Rochester to Windsorcar car
    2. Take the train from Windsor to Aldershottrain train
    3. Take the train from Aldershot to New York Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    30h 58m
    $335–693

  5. Line 492 bus to Detroit, fly to Mcghee Tyson Airport

    1. Take the bus from University Drive & Rochester Nearside to Royal Oak Transit Centerbus bus
    2. Fly from Detroit (DTW) to Mcghee Tyson Airport (TYS)plane plane DTW - TYS
    6h 19m
    $185–838

  6. Fly Detroit to Chattanooga Metropolitan Airport, drive

    1. Fly from Detroit (DTW) to Chattanooga Metropolitan Airport (CHA)plane plane DTW - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    7h 59m
    $168–896

  7. Bus, train via Farragut

    1. Take the bus from Detroit to Toledobus bus
    2. Take the train from Toledo to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    33h 23m
    $436–766

  8. Bus, train

    1. Take the bus from Detroit to Toledobus bus
    2. Take the train from Toledo to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    33h 27m
    $391–676

  9. Bus

    1. Take the bus from Detroit Bus Station to Port Authority Bus Terminalbus bus Greyhound US0420
    2. Take the bus from New York to Knoxvillebus bus Nyc
    34h 4m
    $287–467

Capital Region International Airport (LAN) to Mcghee Tyson Airport (TYS) flights

Calendar39Weekly Planes
Duration5h 26mAverage Duration
Ticket$146Cheapest Price
See schedules

Questions & Answers

Map of how to get from Rochester to Knoxville.ExpandLaunch map view
  • Distance: 578.2 mi
  • Duration: 6h 34m

What companies run services between Rochester, MI, USA and Knoxville, TN, USA?

You can take a bus from University Drive & Rochester Nearside to Knoxville via Jason Hargrove Transit Center Bay 9, Jason Hargrove Transit Center Bay 11, Woodward & Baltimore, Detroit, Toledo Bus Stop, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 30h 20m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound