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How to get fromRochester to St. Louisby car, plane, train (Amtrak), bus (Greyhound), bus, train, or bus (Amtrak, Flixbus)

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There are 8 ways to get from Rochester to St. Louis by car, plane, train (Amtrak), bus (Greyhound), bus, train, or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Windsor Airport, fly

    best
    1. Drive from Rochester to Windsor-Airport-YQGcar car
    2. Fly from Windsor Airport (YQG) to Lambert–St. Louis International Airport (STL)plane plane YQG - STL
    6h 27m
    $191–914

  2. Bus

    cheapest
    1. Take the bus from Detroit, MI to Indianapolis, INbus bus Detroit
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    13h 27m
    $66–144

  3. Train (Amtrak)

    1. Take the train from Royal Oak Amtrak to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    13h 10m
    $182–392

  4. Drive 543 mi

    1. Drive from Rochester to St. Louiscar car 543 mi
    9h 20m
    $100–144

  5. Drive to Capital Region International Airport, fly

    1. Drive from Rochester to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Lambert–St. Louis International Airport (STL)plane plane LAN - STL
    5h 47m
    $118–675

  6. Line 492 bus, train to Detroit, fly

    1. Take the bus from University Drive & Rochester Nearside to Royal Oak Transit Centerbus bus
    2. Take the train from Royal Oak Amtrak to Dearborntrain train
    3. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    6h 39m
    $463–971

  7. Bus to Mbs International Airport, fly

    1. Take the bus from Pontiac Amtrak to Saginaw Bus Centerbus bus
    2. Fly from Mbs International Airport (MBS) to Lambert–St. Louis International Airport (STL)plane plane MBS - STL
    7h 51m
    $151–583

  8. Bus via Chicago

    1. Take the bus from Royal Oak Amtrak to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    14h 49m
    $147–232

Rochester to St. Louis by bus and train (Amtrak)

Calendar21Weekly Services
Duration13h 10mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from Rochester to St. Louis.ExpandLaunch map view
  • Distance: 505.9 mi
  • Duration: 6h 27m

What companies run services between Rochester, MI, USA and St. Louis, MO, USA?

You can take a bus from University Drive & Rochester Nearside to St. Louis via Royal Oak Transit Center, Royal Oak Amtrak, and Chicago Union Station in around 13h 10m. Alternatively, you can take a bus from University Drive & Rochester Nearside to St Louis Bus Station via Jason Hargrove Transit Center Bay 9, Jason Hargrove Transit Center Bay 11, Larned & Griswold, Detroit, MI, and Indianapolis Union Station in around 13h 27m.

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