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How to get fromRochester to Knoxvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Flixbus)

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There are 10 ways to get from Rochester to Knoxville by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Mcghee Tyson Airport

    best
    1. Fly from Rochester (RST) to Mcghee Tyson Airport (TYS)plane plane RST - TYS
    5h 40m
    $186–807

  2. Drive 871.9 mi

    cheapest
    1. Drive from Rochester to Knoxvillecar car 871.9 mi
    14h 51m
    $160–230

  3. Bus via Milwaukee

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    39h 56m
    $406–615

  4. Bus, train via Milwaukee

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 29m
    $535–986

  5. Bus, train

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    43h 48m
    $563–1,037

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    4h 40m
    $275–970

  7. Bus to Minneapolis–Saint Paul International Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Asheville Regional Airport (AVL)plane plane MSP - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 35m
    $172–575

  8. Bus to Minneapolis–Saint Paul International Airport, fly to Nashville, drive

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Nashville (BNA)plane plane MSP - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 52m
    $480–1,050

  9. Bus, train #2

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    45h 17m
    $597–1,139

  10. Bus

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    47h 56m
    $329–509

Rochester (RST) to Mcghee Tyson Airport (TYS) flights

Calendar41Weekly Planes
Duration5h 50mAverage Duration
Ticket$138Cheapest Price
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Questions & Answers

Map of how to get from Rochester to Knoxville.ExpandLaunch map view
  • Distance: 739.1 mi
  • Duration: 5h 40m

What companies run services between Rochester, MN, USA and Knoxville, TN, USA?

Delta, United Airlines, and American Airlines fly from Rochester (RST) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a bus from Rochester to Knoxville via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 39h 56m.

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