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How to get fromRochester to Saint Charlesby plane, bus, train, car, bus (Flixbus, Greyhound), or bus (Greyhound)

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There are 7 ways to get from Rochester to Saint Charles by plane, bus, train, car, bus (Flixbus, Greyhound), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to Lambert–St. Louis International Airport (STL)plane plane RST - STL
    6h 23m
    $95–541

  2. Drive 428.8 mi

    cheapest
    1. Drive from Rochester to Saint Charlescar car 428.8 mi
    7h 53m
    $79–113

  3. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to St. Louistrain train
    16h 14m
    $169–328

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    17h 13m
    $248–503

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL)plane plane MSP - STL
    4h 41m
    $434–1,004

  6. Bus via Chicago

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from Madison to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    18h 18m
    $132–211

  7. Bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Take the bus from Minneapolis Bus Station to Des Moinesbus bus
    3. Take the bus from Des Moines to St Louis Bus Stationbus bus
    20h 52m
    $151–252

Rochester to Saint Charles by bus and train

Calendar7Weekly Services
Duration16h 14mAverage Duration
Ticket$169Cheapest Price
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Questions & Answers

Map of how to get from Rochester to Saint Charles.ExpandLaunch map view
  • Distance: 396 mi
  • Duration: 6h 23m

What companies run services between Rochester, MN, USA and Saint Charles, MO, USA?

United Airlines, American Airlines, and Delta fly from Rochester (RST) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Rochester to 4375 Rider Trail North Sb via Madison, Chicago Bus Station, St Louis Bus Station, Civic Center Transit Center, and North Hanley Transit Center in around 18h 18m.

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