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How to get fromRochester to St. Louisby plane, shuttle, bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Rochester to St. Louis by plane, shuttle, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to Lambert–St. Louis International Airport (STL)plane plane RST - STL
    5h 59m
    $94–540

  2. Drive 448.5 mi

    cheapest
    1. Drive from Rochester to St. Louiscar car 448.5 mi
    8h 13m
    $82–119

  3. Shuttle, bus

    1. Take a shuttle bus from Rochester to Owatonna, MNshuttle bus
    2. Take the bus from Owatonna to Des Moinesbus bus
    3. Take the bus from Des Moines to St Louis Bus Stationbus bus
    14h 57m
    $116–227

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    15h 33m
    $249–499

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL)plane plane MSP - STL
    4h 16m
    $433–1,003

  6. Bus, train via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to St. Louistrain train
    15h 19m
    $174–329

  7. Bus

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    16h
    $137–217

Rochester to St. Louis by bus and train

Calendar21Weekly Services
Duration15h 19mAverage Duration
Ticket$174Cheapest Price
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Questions & Answers

Map of how to get from Rochester to St. Louis.ExpandLaunch map view
  • Distance: 395.9 mi
  • Duration: 5h 59m

What companies run services between Rochester, MN, USA and St. Louis, MO, USA?

United Airlines, American Airlines, and Delta fly from Rochester (RST) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Rochester, MN to St Louis Bus Station via Milwaukee Intermodal Station and Chicago Bus Station in around 16h.

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