There are 6 ways to get from Rochester to Florence by plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Florence Regional Airport
best- Fly from Rochester (ROC) to Florence Regional Airport (FLO)plane ROC - FLO
5h 9m$122–583Bus via Raleigh
- Take the bus from Rochester to New Yorkbus
- Take the bus from Port Authority Bus Terminal to Raleigh Bus Stationbus
- Take the bus from Raleigh Bus Station to Florence Bus Stationbus
20h 50m$176–423Train (Amtrak)
- Take the train from Rochester to Ny Moynihan Train Hall At Penn Stationtrain Empire Service / ...
- Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain Palmetto / ...
22h 46m$555–864Drive 752.9 mi
- Drive from Rochester to Florencecar 752.9 mi
14h 3m$138–199Fly to Myrtle Beach, bus
- Fly from Rochester (ROC) to Myrtle Beach (MYR)plane ROC - MYR
- Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus
5h$125–542Bus
- Take the bus from Rochester Bus Stop to Newark Penn Stationbus
- Take the bus from Newark Penn Station to New York City Chinatownbus
- Take the bus from New York, NY to Florence, SCbus Nyc
21h 10m$147–232
Rochester to Florence by bus
Comparing Your Travel Options
The cheapest way to get from Rochester to Florence is to drive which costs $130 - $200 and takes 14h 3m.
The fastest way to get from Rochester to Florence is to fly and bus which takes 5h and costs $120 - $550.
No, there is no direct bus from Rochester to Florence station. However, there are services departing from Rochester and arriving at Florence Bus Station via Port Authority Bus Terminal and Raleigh Bus Station. The journey, including transfers, takes approximately 20h 50m.
No, there is no direct train from Rochester to Florence station. However, there are services departing from Rochester and arriving at Florence Station via Ny Moynihan Train Hall At Penn Station. The journey, including transfers, takes approximately 22h 46m.
The distance between Rochester and Florence is 637 miles. The road distance is 757.3 miles.
The best way to get from Rochester to Florence without a car is to bus via Raleigh which takes 20h 50m and costs $170 - $430.
It takes approximately 5h 9m to get from Rochester to Florence, including transfers.
Rochester to Florence bus services, operated by Trailways, depart from Rochester station.
Rochester to Florence train services, operated by Amtrak, depart from Rochester station.
The best way to get from Rochester to Florence is to fly which takes 5h 9m and costs $120 - $600. Alternatively, you can bus via Raleigh, which costs $170 - $430 and takes 20h 50m, you could also train, which costs $550 - $900 and takes 22h 46m.
What companies run services between Rochester, NY, USA and Florence, SC, USA?
American Airlines flies from Rochester (ROC) to Florence Regional Airport (FLO) every 4 hours. Alternatively, you can take a bus from Rochester to Florence Bus Station via New York, Port Authority Bus Terminal, and Raleigh Bus Station in around 20h 50m.
- Website
- aa.com
Flights from Rochester to Florence Regional Airport via Charlotte
- Ave. Duration
- 6h 17m
- When
- Every day
- Estimated price
- $95–550
Flights from Rochester to Florence Regional Airport via Reagan Washington, Charlotte
- Ave. Duration
- 7h 34m
- When
- Every day
- Estimated price
- $100–550
Flights from Rochester to Florence Regional Airport via Philadelphia, Charlotte
- Ave. Duration
- 8h 36m
- When
- Every day
- Estimated price
- $100–600
Flights from Rochester to Myrtle Beach via Reagan Washington
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $85–490
Flights from Rochester to Myrtle Beach via Charlotte
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $90–500
Flights from Rochester to Myrtle Beach via Philadelphia
- Ave. Duration
- 4h 45m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $90–500
- Website
- southwest.com
Flights from Rochester to Myrtle Beach via Baltimore
- Ave. Duration
- 3h 45m
- When
- Saturday to Friday
- Estimated price
- $90–490
- Website
- delta.com
Flights from Rochester to Myrtle Beach via New York La Guardia
- Ave. Duration
- 4h 16m
- When
- Every day
- Estimated price
- $100–550
Flights from Rochester to Myrtle Beach via Detroit
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- $100–550
- Website
- flybreeze.com
Flights from Rochester to Myrtle Beach
- Ave. Duration
- 2h 6m
- When
- Thursday and Sunday
- Estimated price
- $180–1,100
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Rochester to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 7h 5m
- Frequency
- 4 times a day
- Estimated price
- $200–320
- Website
- Amtrak
Train from Ny Moynihan Train Hall At Penn Station to Florence Station
- Ave. Duration
- 14h 41m
- Frequency
- Twice daily
- Estimated price
- $350–550
- Website
- Amtrak
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Rochester to New York
- Ave. Duration
- 6h 15m
- Frequency
- Every 4 hours
- Estimated price
- $50–230
- Website
- Trailways
- Schedules at
- Trailways
- Saver
- $50–220
- Flexible
- $95–230
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Port Authority Bus Terminal to Raleigh Bus Station
- Ave. Duration
- 9h 35m
- Frequency
- Every 4 hours
- Estimated price
- $95–150
- Website
- Greyhound
Bus from Raleigh Bus Station to Florence Bus Station
- Ave. Duration
- 3h
- Frequency
- Twice daily
- Estimated price
- $27–45
- Website
- Greyhound
Bus from Myrtle Beach Bus Station to Florence Bus Station
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $12–18
- Website
- Greyhound
Bus from Rochester Bus Stop to Newark Penn Station
- Ave. Duration
- 6h 40m
- Frequency
- Once daily
- Estimated price
- $55–90
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Rochester Bus Stop to Newark Penn Station
- Ave. Duration
- 6h 25m
- Frequency
- 5 times a day
- Estimated price
- $50–80
- Schedules at
- Flixbus USA
Bus from Newark Penn Station to New York City Chinatown
- Ave. Duration
- 45 min
- Frequency
- 3 times a day
- Estimated price
- $10–15
- Schedules at
- Flixbus USA
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from New York, NY to Florence, SC
- Ave. Duration
- 12h
- Frequency
- 3 times a day
- Estimated price
- $85–130
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $85–130
Want to know more about travelling around United States
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Booking & Getting There
Rochester to Florence bus services, operated by Trailways, arrive at New York station.
Rochester to Florence train services, operated by Amtrak, arrive at Ny Moynihan Train Hall At Penn Station.
Yes, the driving distance between Rochester to Florence is 757 miles. It takes approximately 14h 3m to drive from Rochester to Florence.
Book your Rochester to Florence train tickets online with Omio.
Book your Rochester to Florence bus tickets online with Omio.
There are 28+ hotels available in Florence.










