Rome2Rio

How to get fromRochester to Florenceby plane, bus, train (Amtrak), car, or bus (Flixbus, Greyhound)

Find Transport to Florence

See all options

There are 6 ways to get from Rochester to Florence by plane, bus, train (Amtrak), car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Rochester (ROC) to Florence Regional Airport (FLO)plane plane ROC - FLO
    5h 4m
    $127–633

  2. Bus

    1. Take the bus from Rochester to New Yorkbus bus Adt N813-D / ...
    2. Take the bus from New York, NY to Florence, SCbus bus Nyc
    19h 38m
    $142–361

  3. Train (Amtrak)

    1. Take the train from Rochester to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    22h 46m
    $544–863

  4. Drive  753.8 mi

    1. Drive from Rochester to Florencecar car 753.8 mi
    14h 1m
    $134–193

  5. Fly to Myrtle Beach, bus

    1. Fly from Rochester (ROC) to Myrtle Beach (MYR)plane plane ROC - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    5h
    $135–603

  6. Bus via Fayetteville

    1. Take the bus from Rochester Bus Stop to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Florence Bus Stationbus bus
    20h 15m
    $154–243

Rochester to Florence by train (Amtrak)

Calendar14Weekly Trains
Duration22h 46mAverage Duration
Ticket$544Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Rochester to Florence.ExpandLaunch map view
  • Distance: 633.7 mi
  • Duration: 5h 4m

What companies run services between Rochester, NY, USA and Florence, SC, USA?

American Airlines flies from Rochester (ROC) to Florence Regional Airport (FLO) every 4 hours. Alternatively, you can take a bus from Rochester to Florence, SC via New York, 42 St-Times Square, Canal St, and New York, NY in around 19h 38m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There