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How to get fromRochester to Knoxvilleby plane, bus, car, bus (Flixbus), or train

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There are 7 ways to get from Rochester to Knoxville by plane, bus, car, bus (Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (ROC) to Mcghee Tyson Airport (TYS)plane plane ROC - TYS
    4h 15m
    $252–1,040

  2. Drive 750.8 mi

    cheapest
    1. Drive from Rochester to Knoxvillecar car 750.8 mi
    12h 41m
    $137–198

  3. Bus

    1. Take the bus from Rochester to New Yorkbus bus Adt N813 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    19h 55m
    $237–481

  4. Bus to Buffalo Niagara International Airport, fly

    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    6h 16m
    $255–1,087

  5. Bus via New York

    1. Take the bus from Rochester Bus Stop to New York Midtownbus bus FlixBus 2685 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    20h 51m
    $238–343

  6. Train, bus via Albany

    1. Take the train from Rochester to Albany-Rensselaer Amtrak Stationtrain train
    2. Take the train from Albany-Rensselaer Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    21h 5m
    $245–469

  7. Train, bus

    1. Take the train from Rochester to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    21h 22m
    $283–512

Rochester (ROC) to Mcghee Tyson Airport (TYS) flights

Calendar78Weekly Planes
Duration4h 39mAverage Duration
Ticket$184Cheapest Price
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Questions & Answers

Map of how to get from Rochester to Knoxville.ExpandLaunch map view
  • Distance: 624.6 mi
  • Duration: 4h 15m

What companies run services between Rochester, NY, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and two other airlines fly from Rochester (ROC) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a bus from Rochester to Knoxville via New York, 47-50 Sts-Rockefeller Ctr, East Broadway, New York, and Knoxville in around 19h 55m.

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