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How to get fromRochester to Louisvilleby plane, train, bus, bus (Greyhound, Amtrak), car, or bus (Flixbus, Greyhound, Amtrak)

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There are 9 ways to get from Rochester to Louisville by plane, train, bus, bus (Greyhound, Amtrak), car, or bus (Flixbus, Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Louisville International Airport

    best
    1. Fly from Rochester (ROC) to Louisville International Airport (SDF)plane plane ROC - SDF
    5h 9m
    $178–973

  2. Bus via Toledo

    cheapest
    1. Take the bus from Rochester Bus Stop to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Indianapolisbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    15h 50m
    $104–205

  3. Train, bus via Toledo

    1. Take the train from Rochester to Toledotrain train
    2. Take the bus from Toledo to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    14h 44m
    $238–409

  4. Drive  598.9 mi

    1. Drive from Rochester to Louisvillecar car 598.9 mi
    10h 12m
    $110–158

  5. Fly Rochester to Blue Grass Airport, drive

    1. Fly from Rochester (ROC) to Blue Grass Airport (LEX)plane plane ROC - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 15m
    $125–589

  6. Bus to Buffalo Niagara International Airport, fly to Louisville International Airport

    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    7h 5m
    $121–717

  7. Train, bus

    1. Take the train from Rochester to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    14h 59m
    $252–404

  8. Bus

    1. Take the bus from Rochester to Buffalobus bus 308 / ...
    2. Take the bus from Buffalo to Columbusbus bus
    3. Take the bus from Columbus to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    17h 24m
    $117–218

  9. Train, bus #2 (Amtrak)

    1. Take the train from Rochester to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    20h 32m
    $445–710

Rochester to Louisville by train and bus

Calendar7Weekly Services
Duration14h 44mAverage Duration
Ticket$238Cheapest Price
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Comparing Your Travel Options

Map of how to get from Rochester to Louisville.ExpandLaunch map view
  • Distance: 553.7 mi
  • Duration: 5h 9m

What companies run services between Rochester, NY, USA and Louisville, KY, USA?

Delta, Southwest Airlines, and two other airlines fly from Rochester (ROC) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Rochester Bus Stop to Louisville, KY via Cleveland Bus Station, Toledo, and Indianapolis Union Station in around 15h 50m.

Airlines
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