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How to get fromRochester to Louisvilleby plane, train, bus, car, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Rochester to Louisville by plane, train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Louisville International Airport

    best
    1. Fly from Rochester (ROC) to Louisville International Airport (SDF)plane plane ROC - SDF
    5h 4m
    $168–873

  2. Bus

    cheapest
    1. Take the bus from Rochester Bus Stop to Buffalobus bus
    2. Take the bus from Buffalo, NY to Cincinnati, OHbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    15h 15m
    $73–141

  3. Train, bus

    1. Take the train from Rochester to Toledotrain train Lake Shore Limited
    2. Take the bus from Toledo Bus Stop to Louisville Bus Stationbus bus Greyhound US0135 / ...
    13h 34m
    $139–279

  4. Bus via Akron

    1. Take the bus from Rochester to Buffalobus bus 308 / ...
    2. Take the bus from Buffalo to Akronbus bus
    3. Take the bus from Akron to Louisvillebus bus
    14h 20m
    $76–195

  5. Drive  598.9 mi

    1. Drive from Rochester to Louisvillecar car 598.9 mi
    10h 12m
    $110–158

  6. Fly Rochester to Blue Grass Airport, drive

    1. Fly from Rochester (ROC) to Blue Grass Airport (LEX)plane plane ROC - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 7m
    $120–589

  7. Bus to Buffalo Niagara International Airport, fly to Louisville International Airport

    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    6h 55m
    $121–668

Rochester to Louisville by train and bus

Calendar14Weekly Services
Duration13h 34mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from Rochester to Louisville.ExpandLaunch map view
  • Distance: 553.7 mi
  • Duration: 5h 4m

What companies run services between Rochester, NY, USA and Louisville, KY, USA?

Delta, Southwest Airlines, and two other airlines fly from Rochester (ROC) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Rochester to Louisville via Buffalo and Akron in around 14h 20m.

Airlines
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Bus operators

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