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How to get fromRochester to Mayo Clinicby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 8 ways to get from Rochester to Mayo Clinic by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Rochester

    best
    1. Fly from Rochester (ROC) to Rochester (RST)plane plane ROC - RST
    5h 55m
    $128–660

  2. Bus to Buffalo Niagara International Airport, fly to Rochester

    cheapest
    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Rochester (RST)plane plane BUF - RST
    7h 46m
    $91–494

  3. Train, bus via Madison

    1. Take the train from Rochester to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    21h 29m
    $228–466

  4. Bus

    1. Take the bus from Rochester Bus Stop to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    22h 58m
    $176–274

  5. Drive  945.3 mi

    1. Drive from Rochester to Mayo Cliniccar car 945.3 mi
    15h 57m
    $173–250

  6. Fly Rochester to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Rochester (ROC) to Minneapolis–Saint Paul International Airport (MSP)plane plane ROC - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 11m
    $199–772

  7. Bus to Buffalo Niagara International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Minneapolis–Saint Paul International Airport (MSP)plane plane BUF - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 20m
    $162–616

  8. Train, bus

    1. Take the train from Rochester to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    22h 47m
    $281–616

Rochester to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration21h 29mAverage Duration
Ticket$228Cheapest Price
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Comparing Your Travel Options

Map of how to get from Rochester to Mayo Clinic.ExpandLaunch map view
  • Distance: 757.3 mi
  • Duration: 5h 55m

What companies run services between Rochester, NY, USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines, and Delta fly from Rochester (ROC) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Rochester Bus Stop to Mayo Clinic via Cleveland Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 22h 58m.

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