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How to get fromRochester to Mechanicsburgby bus (Greyhound), train (Amtrak), car, plane, train, or bus (Flixbus, Greyhound)

Find Transport to Mechanicsburg

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There are 7 ways to get from Rochester to Mechanicsburg by bus (Greyhound), train (Amtrak), car, plane, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Rochester to Binghamtonbus bus 231 / ...
    2. Take the bus from Binghamton to Scranton Bus Stationbus bus
    3. Take the bus from Scranton, Pa to Harrisburg, Pabus bus 771
    10h 14m
    $64–189

  2. Drive  252.9 mi

    cheapest
    1. Drive from Rochester to Mechanicsburgcar car 252.9 mi
    5h 15m
    $45–65

  3. Train (Amtrak)

    1. Take the train from Rochester to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Harrisburgtrain train Keystone Service / ...
    12h 32m
    $305–485

  4. Fly to Philadelphia International Airport, train

    1. Fly from Rochester (ROC) to Philadelphia International Airport (PHL)plane plane ROC - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    6h 16m
    $155–666

  5. Bus via Syracuse

    1. Take the bus from Rochester Bus Stop to Syracuse Bus Stationbus bus
    2. Take the bus from Syracuse Bus Station to Scranton Bus Stationbus bus
    3. Take the bus from Scranton, Pa to Harrisburg, Pabus bus 771
    10h 24m
    $63–140

  6. Fly to John F. Kennedy International Airport, train

    1. Fly from Rochester (ROC) to John F. Kennedy International Airport (JFK)plane plane ROC - JFK
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Harrisburgtrain train
    7h 33m
    $182–571

  7. Fly to Laguardia Airport, train

    1. Fly from Rochester (ROC) to Laguardia Airport (LGA)plane plane ROC - LGA
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Harrisburgtrain train
    7h 40m
    $216–848

Rochester to Mechanicsburg by bus and foot

Calendar7Weekly Services
Duration10h 14mAverage Duration
Ticket$64Cheapest Price
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Comparing Your Travel Options

Map of how to get from Rochester to Mechanicsburg.ExpandLaunch map view
  • Distance: 351.4 mi
  • Duration: 10h 14m

What companies run services between Rochester, NY, USA and Mechanicsburg, Cumberland County, PA, USA?

You can take a bus from Rochester to E Main St & Arch St WB via Binghamton, Scranton, Pa, Harrisburg, Pa, and Market Square Transfer Center in around 10h 14m. Alternatively, you can take a train from Rochester to E Main St & Arch St WB via Ny Moynihan Train Hall At Penn Station, Harrisburg, and Market Square Transfer Center in around 12h 32m.

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