There are 7 ways to get from Rochester to Sanford by plane, taxi, bus (Greyhound), train (Amtrak), car, train, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Portland, taxi
best- Fly from Rochester (ROC) to Portland (PWM)plane ROC - PWM
- Take the taxi from Portland-Airport-PWM to Sanfordtaxi
4h 39m$437–1,150Drive 412.4 mi
cheapest- Drive from Rochester to Sanfordcar 412.4 mi
8h 33m$76–109Bus (Greyhound)
- Take the bus from Rochester Bus Stop to Bostonbus Greyhound US0171
- Take the bus from Boston to Wells Transportation Centerbus Greyhound US0265s
11h 41m$111–191Train (Amtrak)
- Take the train from Rochester to Bostontrain Lake Shore Limited
- Take the train from Boston to Wellstrain Downeaster
13h 39m$205–399Fly to Manchester Airport, drive
- Fly from Rochester (ROC) to Manchester Airport (MHT)plane ROC - MHT
- Drive from Manchester-Airport-MHT to Sanfordcar
5h 31m$112–525Fly to Boston Logan Airport, train
- Fly from Rochester (ROC) to Boston Logan Airport (BOS)plane ROC - BOS
- Take the train from Woburn Amtrak Station to Wellstrain
5h 19m$153–534Bus via Ithaca
- Take the bus from Rochester Bus Stop to Ithacabus
- Take the bus from Ithaca to Bostonbus
- Take the bus from Boston to Wells Transportation Centerbus
14h 6m$125–201
Rochester (ROC) to Portland (PWM) flights
Questions & Answers
The cheapest way to get from Rochester to Sanford is to drive which costs $75 - $110 and takes 8h 33m.
The fastest way to get from Rochester to Sanford is to fly and taxi which takes 4h 39m and costs $430 - $1,200.
No, there is no direct bus from Rochester to Sanford. However, there are services departing from Rochester Bus Stop and arriving at Wells Transportation Center via Boston. The journey, including transfers, takes approximately 11h 41m.
No, there is no direct train from Rochester to Sanford. However, there are services departing from Rochester and arriving at Wells via Back Bay and Boston. The journey, including transfers, takes approximately 13h 39m.
The distance between Rochester and Sanford is 410 miles. The road distance is 414.8 miles.
The best way to get from Rochester to Sanford without a car is to bus which takes 11h 41m and costs $110 - $200.
It takes approximately 4h 39m to get from Rochester to Sanford, including transfers.
Rochester to Sanford bus services, operated by Greyhound USA, depart from Rochester Bus Stop station.
Rochester to Sanford train services, operated by Amtrak, depart from Rochester station.
The best way to get from Rochester to Sanford is to bus which takes 11h 41m and costs $110 - $200. Alternatively, you can train, which costs $200 - $400 and takes 13h 39m.
What companies run services between Rochester, NY, USA and Sanford, ME, USA?
You can take a bus from Rochester Bus Stop to Sanford via Boston and Wells Transportation Center in around 11h 41m. Alternatively, you can take a train from Rochester to Sanford via Boston, Back Bay, North Station, Boston, and Wells in around 13h 39m.
- Website
- aa.com
Flights from Rochester to Portland via Philadelphia
- Ave. Duration
- 5h 38m
- When
- Every day
- Estimated price
- $100–600
Flights from Rochester to Portland via Reagan Washington
- Ave. Duration
- 5h 24m
- When
- Every day
- Estimated price
- $120–600
Flights from Rochester to Manchester Airport via Philadelphia
- Ave. Duration
- 6h 18m
- When
- Every day
- Estimated price
- $85–490
Flights from Rochester to Manchester Airport via Reagan Washington
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $100–550
Flights from Rochester to Manchester Airport via Charlotte
- Ave. Duration
- 7h 36m
- When
- Every day
- Estimated price
- $160–700
Flights from Rochester to Boston Logan Airport
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $65–400
- Website
- southwest.com
Flights from Rochester to Portland via Baltimore
- Ave. Duration
- 5h 37m
- When
- Every day
- Estimated price
- $110–600
Flights from Rochester to Manchester Airport via Baltimore
- Ave. Duration
- 5h 32m
- When
- Every day
- Estimated price
- $95–550
Flights from Rochester to Manchester Airport via Chicago Midway
- Ave. Duration
- 5h 42m
- When
- Sunday
- Estimated price
- $160–750
Flights from Rochester to Boston Logan Airport via Baltimore
- Ave. Duration
- 3h 47m
- When
- Sunday and Saturday
- Estimated price
- $90–480
- Website
- united.com
Flights from Rochester to Portland via Washington Dulles
- Ave. Duration
- 4h 14m
- When
- Every day
- Estimated price
- $120–600
Flights from Rochester to Portland via Newark
- Ave. Duration
- 6h 8m
- When
- Every day
- Estimated price
- $95–550
Flights from Rochester to Manchester Airport via Washington Dulles
- Ave. Duration
- 5h 25m
- When
- Every day
- Estimated price
- $100–550
Flights from Rochester to Boston Logan Airport via Newark
- Ave. Duration
- 3h 48m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $70–430
- Website
- delta.com
Flights from Rochester to Portland via New York La Guardia
- Ave. Duration
- 4h 2m
- When
- Sunday, Monday, Tuesday, Wednesday, Thursday, and Friday
- Estimated price
- $95–550
Flights from Rochester to Portland via Detroit
- Ave. Duration
- 5h 58m
- When
- Every day
- Estimated price
- $140–700
- Website
- jetblue.com
Flights from Rochester to Portland via New York JFK
- Ave. Duration
- 5h 43m
- When
- Every day
- Estimated price
- $95–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Rochester to Boston
- Ave. Duration
- 10h 18m
- Frequency
- Once daily
- Estimated price
- $130–290
- Website
- Amtrak
Train from Boston to Wells
- Ave. Duration
- 1h 48m
- Frequency
- 5 times a day
- Estimated price
- $26–60
- Website
- Amtrak
Train from Woburn Amtrak Station to Wells
- Ave. Duration
- 1h 30m
- Frequency
- 5 times a day
- Estimated price
- $22–50
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Rochester Bus Stop to Boston
- Ave. Duration
- 8h 40m
- Frequency
- Twice daily
- Estimated price
- $60–120
- Website
- Greyhound
Bus from Boston to Wells Transportation Center
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $11–23
- Website
- Greyhound
Bus from Boston to Wells Transportation Center
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $11–23
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Rochester Bus Stop to Ithaca
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- $14–24
- Schedules at
- Flixbus USA
Bus from Ithaca to Boston
- Ave. Duration
- 7h 55m
- Frequency
- 6 times a week
- Estimated price
- $60–100
- Schedules at
- Flixbus USA
- Ave. Duration
- 42 min
- Estimated price
- $100–130
207 Taxi
- Phone
- +1 207-774-2255
- Website
- 207taxi.com
ABC Taxi
- Phone
- +1 207-772-8685
- Website
- abctaxiportland.com
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More Questions & Answers
Rochester to Sanford bus services, operated by Greyhound USA, arrive at Boston station.
Rochester to Sanford train services, operated by Amtrak, arrive at Boston station.
Yes, the driving distance between Rochester to Sanford is 415 miles. It takes approximately 8h 33m to drive from Rochester to Sanford.
There are 169+ hotels available in Sanford.






