There are 6 ways to get from Rome to Mesagne by train (Trenitalia), bus, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Trenitalia)
best- Take the train from Roma Termini to Brindisitrain Fr / ...
6h 29m€90–173Bus via Rome Tiburtina Largo Mazzoni
cheapest- Take the bus from Rome Tiburtina Largo Mazzoni to Ostuni Viale dello Sportbus Itabus
8h 55m€33–63Bus
- Take the bus from Roma, Autostazione Tiburtina to Ostunibus N573
8h 35m€44–73Drive 534.1 km
- Drive from Rome to Mesagnecar 534.1 km
6h 9m€84–121Fly to Brindisi Airport, bus
- Fly from Fiumicino International Airport (FCO) to Brindisi Airport (BDS)plane FCO - BDS
- Take the bus from Borgo Casale to Mesagnebus
4h 50m€35–177Fly to Lamezia Terme International Airport, drive
- Fly from Fiumicino International Airport (FCO) to Lamezia Terme International Airport (SUF)plane FCO - SUF
- Drive from Lamezia-Terme-Airport-SUF to Mesagnecar
6h 34m€94–226
Rome to Mesagne by bus
Questions & Answers
The cheapest way to get from Rome to Mesagne is to bus via Rome Tiburtina Largo Mazzoni which costs €30 - €65 and takes 8h 55m.
The fastest way to get from Rome to Mesagne is to fly and bus which takes 4h 50m and costs €35 - €180.
No, there is no direct bus from Rome to Mesagne. However, there are services departing from Roma, Autostazione Tiburtina and arriving at Mesagne via Ostuni - viale Dello Sport. The journey, including transfers, takes approximately 8h 35m.
No, there is no direct train from Rome to Mesagne. However, there are services departing from Roma Termini and arriving at Brindisi via . The journey, including transfers, takes approximately 6h 29m.
The distance between Rome and Mesagne is 606 km. The road distance is 534.1 km.
The best way to get from Rome to Mesagne without a car is to train which takes 6h 29m and costs €90 - €180.
It takes approximately 6h 29m to get from Rome to Mesagne, including transfers.
Rome to Mesagne bus services, operated by FlixBus, depart from Roma, Autostazione Tiburtina station.
Rome to Mesagne train services, operated by Trenitalia Frecce, depart from Roma Termini station.
The best way to get from Rome to Mesagne is to train which takes 6h 29m and costs €90 - €180. Alternatively, you can bus, which costs €40 - €75 and takes 8h 35m.
What companies run services between Rome, Italy and Mesagne, Italy?
Trenitalia Frecce operates a train from Roma Termini to Brindisi every 2 hours. Tickets cost €85–180 and the journey takes 5h 22m. Alternatively, FlixBus operates a bus from Roma, Autostazione Tiburtina to Ostuni once daily. Tickets cost €40–70 and the journey takes 6h 55m.
- Website
- ita-airways.com
Flights from Fiumicino International Airport to Brindisi Airport
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- €50–180
Flights from Fiumicino International Airport to Lamezia Terme International Airport
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- €45–160
- Website
- ryanair.com
Flights from Fiumicino International Airport to Brindisi Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €26–160
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Brindisi
- Ave. Duration
- 5h 22m
- Frequency
- Every 2 hours
- Estimated price
- €85–180
- Schedules at
- trenitalia.com
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- https://www.flixbus.fr
Bus from Roma, Autostazione Tiburtina to Ostuni
- Ave. Duration
- 6h 55m
- Frequency
- Once daily
- Estimated price
- €40–70
- Website
- https://www.flixbus.co.uk
- Phone
- 800232042, 3667880781
- Website
- stpbrindisi.it
Bus from Borgo Casale to Mesagne
- Ave. Duration
- 35 min
- Frequency
- Every 3 hours
- Estimated price
- €1
- Schedules at
- stpbrindisi.it
 "STP Brindisi bus")
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Rome Tiburtina Largo Mazzoni to Ostuni Viale dello Sport
- Ave. Duration
- 7h 15m
- Frequency
- Once daily
- Estimated price
- €30–60
- Website
- https://www.itabus.it/en/home
Want to know more about travelling around Italy
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Related travel guides
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More Questions & Answers
Rome to Mesagne bus services, operated by FlixBus, arrive at Ostuni station.
Rome to Mesagne train services, operated by Trenitalia Frecce, arrive at Brindisi station.
Yes, the driving distance between Rome to Mesagne is 534 km. It takes approximately 6h 9m to drive from Rome to Mesagne.
Book your Rome to Mesagne train tickets online with Omio.
There are 1872+ hotels available in Mesagne.