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How to get fromRome to Santa Maria del Moliseby train (Trenitalia), bus, or car

Find Transport to Santa Maria del Molise

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There are 3 ways to get from Rome to Santa Maria del Molise by train (Trenitalia), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Trenitalia)

    best
    1. Take the train from Roma Termini to Iserniatrain train Re
    3h 30m
    €24–39
  2. Bus

    cheapest
    1. Take the bus from Roma, Autostazione Tiburtina to Iserniabus bus Rome Tiburtina
    3h 32m
    €10–27
  3. Drive 189.2 km

    1. Drive from Rome to Santa Maria del Molisecar car 189.2 km
    2h 13m
    €30–43

Questions & Answers

What companies run services between Rome, Italy and Santa Maria del Molise, Italy?

Trenitalia operates a train from Roma Termini to Isernia every 3 hours. Tickets cost €23–40 and the journey takes 2h 8m. Alternatively, ATM Azienda di Trasporti Molisana S.p.A. operates a bus from Roma, Autostazione Tiburtina to Isernia 3 times a day. Tickets cost €8–13 and the journey takes 2h 10m. FlixBus also services this route once daily.

Train operators
Bus operators

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