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How to get fromSaint Augustine to Florida Keysby car, bus, or plane

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There are 5 ways to get from Saint Augustine to Florida Keys by car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive 466.6 mi

    best
    1. Drive from Saint Augustine to Key Westcar car 466.6 mi
    8h 35m
    $86–123

  2. Drive to Orlando Sanford, fly

    cheapest
    1. Drive from Saint Augustine to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    3h 7m
    $51–273

  3. Bus to Jacksonville, fly

    1. Take the bus from St. Johns Adminsistration to Pearl St. & Bay St.bus bus
    2. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    7h 27m
    $373–820

  4. Bus to Orlando, fly

    1. Take the bus from Jacksonville to Orlando Bus Stationbus bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    7h 4m
    $144–745

  5. Bus, bus to Gainesville Regional Airport, fly

    1. Take the bus from St. Johns Adminsistration to JRTC - Express Selectbus bus
    2. Take the bus from Jacksonville to Gainesvillebus bus
    3. Fly from Gainesville Regional Airport (GNV) to Key West International Airport (EYW)plane plane GNV - EYW
    9h 44m
    $64–307

Jacksonville (JAX) to Key West International Airport (EYW) flights

Calendar51Weekly Planes
Duration5h 6mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

Map of how to get from Saint Augustine to Florida Keys.ExpandLaunch map view
  • Distance: 466.6 mi
  • Duration: 8h 35m

What companies run services between Saint Augustine, FL, USA and Florida Keys, Monroe County, FL, USA?

You can drive from Saint Augustine to Key West in around 8h 35m.

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Bus operators

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