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How to get fromSaint Charles to Cape Girardeauby bus, plane, train, taxi, car, or bus (Flixbus, Greyhound)

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There are 9 ways to get from Saint Charles to Cape Girardeau by bus, plane, train, taxi, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Cape Girardeau Municipal Airport

    best
    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane plane ORD - CGI
    3h 54m
    $158–299

  2. Drive 371.5 mi

    cheapest
    1. Drive from Saint Charles to Cape Girardeaucar car 371.5 mi
    7h 1m
    $68–98

  3. Train, taxi

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to Carbondaletrain train
    3. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    8h 56m
    $215–365

  4. Train, bus, taxi

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Take the bus from Chicago to Anna - Shellbus bus
    3. Take the taxi from Anna - Shell to Cape Girardeautaxi taxi
    10h 1m
    $160–295

  5. Bus, fly to Williamson County Regional Airport, taxi

    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane plane ORD - MWA
    3. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    4h 35m
    $250–421

  6. Bus, fly to Barkley Regional Airport, taxi

    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane plane ORD - PAH
    3. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    5h
    $225–521

  7. Bus, fly to Lambert–St. Louis International Airport

    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    7h 7m
    $377–798

  8. Train, bus

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    10h 21m
    $129–259

  9. Bus

    1. Take the bus from Downers Grove to Illinois Terminalbus bus
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    10h 37m
    $171–242

Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI) flights

Calendar7Weekly Planes
Duration1h 40mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Cape Girardeau.ExpandLaunch map view
  • Distance: 386.3 mi
  • Duration: 3h 54m

What companies run services between Saint Charles, IL, USA and Cape Girardeau, MO, USA?

You can take a vehicle from Saint Charles to Cape Girardeau via Downers Grove, Illinois Terminal, Champaign Intermodal Trans Ctr, St Louis Bus Station, and Cape Girardeau in around 10h 37m.

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