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How to get fromSaint Charles to Mayo Clinicby bus, plane, train, or car

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There are 8 ways to get from Saint Charles to Mayo Clinic by bus, plane, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 41m
    $81–381

  2. Drive 318.6 mi

    cheapest
    1. Drive from Saint Charles to Mayo Cliniccar car 318.6 mi
    5h 19m
    $59–84

  3. Bus

    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus 603
    2. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    10h 22m
    $112–172

  4. Train, bus

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    12h 30m
    $168–335

  5. Bus to Chicago O'Hare International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 24m
    $312–553

  6. Train to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 43m
    $141–529

  7. Train, bus via Milwaukee

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    10h 43m
    $116–180

  8. Train, bus via Madison

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Take the bus from Chicago Bus Station to Madisonbus bus
    3. Take the bus from Madison to Rochesterbus bus
    11h 45m
    $95–150

Chicago O'Hare International Airport (ORD) to Rochester (RST) flights

Calendar35Weekly Planes
Duration1h 53mAverage Duration
Ticket$43Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Mayo Clinic.ExpandLaunch map view
  • Distance: 315.7 mi
  • Duration: 4h 41m

What companies run services between Saint Charles, IL, USA and Mayo Clinic, MN, USA?

You can take a vehicle from Saint Charles to Mayo Clinic via Elgin Transportation Center Bay 4, Rosemont CTA Station, Multi-Modal/Rental Car Facility, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 10h 22m.

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