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How to get fromSaint Charles to St. Louisby bus, plane, train (Amtrak), bus (Flixbus), car, or train

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There are 5 ways to get from Saint Charles to St. Louis by bus, plane, train (Amtrak), bus (Flixbus), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Chicago O'Hare International Airport, fly

    best
    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    3h 58m
    $313–754

  2. Drive 280.6 mi

    cheapest
    1. Drive from Saint Charles to St. Louiscar car 280.6 mi
    4h 59m
    $52–74

  3. Train

    1. Take the train from Geneva to Chicago OTCtrain train Up-W
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    7h 12m
    $105–215

  4. Bus

    1. Take the bus from Downers Grove to Illinois Terminalbus bus Chicago to Champaign via shopping SB / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus N2521 / ...
    7h 23m
    $148–198

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    5h 13m
    $97–580

Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) flights

Calendar109Weekly Planes
Duration1h 28mAverage Duration
Ticket$62Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to St. Louis.ExpandLaunch map view
  • Distance: 310.9 mi
  • Duration: 3h 58m

What companies run services between Saint Charles, IL, USA and St. Louis, MO, USA?

You can take a vehicle from Saint Charles to St. Louis via Geneva, Chicago OTC, Madison & Canal, Clinton & Jackson, and Chicago Union Station in around 7h 12m. Alternatively, you can take a vehicle from Saint Charles to St Louis Bus Station via Downers Grove, Illinois Terminal, and Champaign Intermodal Trans Ctr in around 7h 23m.

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