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How to get fromSaint Charles to Charlestonby bus, plane, bus (Greyhound, Flixbus), or car

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There are 4 ways to get from Saint Charles to Charleston by bus, plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 34 bus, fly to Charleston International Airport

    best
    1. Take the bus from 4375 Rider Trail North Sb to North Hanley Transit Centerbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Charleston International Airport (CHS)plane plane STL - CHS
    5h 12m
    $106–556

  2. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    27h 50m
    $153–308

  3. Drive 860.7 mi

    1. Drive from Saint Charles to Charlestoncar car 860.7 mi
    15h 3m
    $158–227

  4. Fly to Hilton Head Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Hilton Head Airport (HHH)plane plane STL - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 59m
    $117–531

Saint Charles to Charleston by bus and train

Calendar14Weekly Services
Duration27h 50mAverage Duration
Ticket$153Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Charleston.ExpandLaunch map view
  • Distance: 736.1 mi
  • Duration: 5h 12m

What companies run services between Saint Charles, MO, USA and Charleston, SC, USA?

You can take a bus from 4375 Rider Trail North Sb to Transit Mall via North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St Louis Bus Station, Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 27h 50m.

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