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How to get fromSaint Charles to Chicagoby taxi, bus, plane, train (Amtrak), bus (Flixbus), or car

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There are 5 ways to get from Saint Charles to Chicago by taxi, bus, plane, train (Amtrak), bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, line 34 bus, fly to Chicago Midway International Airport

    best
    1. Take the taxi from Saint Charles to 4375 Rider Trail North Sbtaxi taxi
    2. Take the bus from 4375 Rider Trail North Sb to North Hanley Transit Centerbus bus
    3. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    3h 38m
    $69–375

  2. Drive  306.6 mi

    cheapest
    1. Drive from Saint Charles to Chicagocar car 306.6 mi
    5h 20m
    $56–81

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    6h 50m
    $167–259

  4. Bus (Flixbus)

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
    8h 46m
    $65–93

  5. Line 34 bus, fly to Chicago O'Hare International Airport

    1. Take the bus from 4375 Rider Trail North Sb to North Hanley Transit Centerbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    4h 4m
    $289–725

Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW) flights

Calendar32Weekly Planes
Duration1h 6mAverage Duration
Ticket$51Cheapest Price
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Comparing Your Travel Options

Map of how to get from Saint Charles to Chicago.ExpandLaunch map view
  • Distance: 283.6 mi
  • Duration: 3h 38m

What companies run services between Saint Charles, MO, USA and Chicago, IL, USA?

Amtrak operates a train from St. Louis to Chicago Union Station 5 times a day. Tickets cost $150–240 and the journey takes 4h 55m. Alternatively, Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station twice daily. Tickets cost $50–75 and the journey takes 6h 5m.

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