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How to get fromSaint Charles to Des Moinesby plane, bus (Greyhound), car, bus, or train

Find Transport to Des Moines

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There are 5 ways to get from Saint Charles to Des Moines by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane plane STL - DSM
    5h 15m
    $161–775

  2. Drive 311.3 mi

    cheapest
    1. Drive from Saint Charles to Des Moinescar car 311.3 mi
    6h 15m
    $57–83

  3. Bus (Greyhound)

    1. Take the bus from St Louis Bus Station to Des Moinesbus bus Greyhound US0153S
    10h 31m
    $69–134

  4. Bus via Iowa City

    1. Take the bus from Saint Louis to Iowa Citybus bus Btw 1490
    2. Take the bus from Iowa City to Des Moinesbus bus Btw 1205 / ...
    11h 13m
    $109–154

  5. Train, bus

    1. Take the train from St. Louis to Bloomington-Normaltrain train Lincoln Service / ...
    2. Take the bus from Bloomington-Normal to Des Moinesbus bus Greyhound US0157S
    11h 57m
    $99–204

Saint Charles to Des Moines by bus and train (Greyhound)

Calendar7Weekly Services
Duration10h 31mAverage Duration
Ticket$69Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Des Moines.ExpandLaunch map view
  • Distance: 282.2 mi
  • Duration: 5h 15m

What companies run services between Saint Charles, MO, USA and Des Moines, IA, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM) hourly. Alternatively, Greyhound USA operates a bus from St Louis Bus Station to Des Moines once daily. Tickets cost $65–130 and the journey takes 8h 30m.

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