What is the cheapest way to get from Saint Charles to Des Moines?

The cheapest way to get from Saint Charles to Des Moines is to drive which costs $55 - $85 and takes 6h 15m.

What is the fastest way to get from Saint Charles to Des Moines?

The fastest way to get from Saint Charles to Des Moines is to fly which takes 5h 50m and costs $100 - $470.

Is there a direct bus between Saint Charles and Des Moines?

No, there is no direct bus from Saint Charles to Des Moines. However, there are services departing from 4375 Rider Trail North Sb and arriving at Des Moines via North Hanley Transit Center, St Louis Bus Station and Kansas City. The journey, including transfers, takes approximately 11h 6m.

How far is it from Saint Charles to Des Moines?

The distance between Saint Charles and Des Moines is 288 miles. The road distance is 313.1 miles.

How do I travel from Saint Charles to Des Moines without a car?

The best way to get from Saint Charles to Des Moines without a car is to bus which takes 11h 6m and costs $100 - $160.

How long does it take to get from Saint Charles to Des Moines?

It takes approximately 5h 50m to get from Saint Charles to Des Moines, including transfers.

Where do I catch the Saint Charles to Des Moines bus from?

Saint Charles to Des Moines bus services, operated by Greyhound USA, depart from St Louis Bus Station.

Bus or fly from Saint Charles to Des Moines?

The best way to get from Saint Charles to Des Moines is to fly which takes 5h 50m and costs $100 - $470. Alternatively, you can bus, which costs $100 - $160 and takes 11h 6m.

Where does the Saint Charles to Des Moines bus arrive?

Saint Charles to Des Moines bus services, operated by Greyhound USA, arrive at Kansas City Bus Station.

Can I drive from Saint Charles to Des Moines?

Yes, the driving distance between Saint Charles to Des Moines is 313 miles. It takes approximately 6h 15m to drive from Saint Charles to Des Moines.

Where can I stay near Des Moines?

There are 254+ hotels available in Des Moines.

Saint Charles to Des Moines - 5 ways to travel via train, plane, bus, and car

How to get fromSaint Charles to Des Moines

Travel from

See all options

Search accommodation with Expedia

There are 5 ways to get from Saint Charles to Des Moines by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly
best
1. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane STL - DSM
5h 50m
$105–463
Drive 311.3 mi
cheapest
1. Drive from Saint Charles to Des Moinescar 311.3 mi
6h 15m
$57–83
Bus
1. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus Greyhound US0180s / ...
2. Take the bus from Kansas City to Des Moinesbus Jefferson Lines 804 / ...
11h 6m
$105–158
Train, bus via Kansas City
1. Take the train from St. Louis to Kansas Citytrain Missouri River Runner / ...
2. Take the bus from Kansas City Bus Station to Des Moinesbus Greyhound US0156
12h 32m
$122–269
Train, bus
1. Take the train from St. Louis to Bloomington-Normaltrain Lincoln Service / ...
2. Take the bus from Bloomington-Normal to Des Moinesbus Greyhound US0157S
12h 11m
$102–205

Lambert–St. Louis International Airport (STL) to Des Moines (DSM) flights

128Weekly Planes

4h 56mAverage Duration

$72Cheapest Price

See schedules

Comparing Your Travel Options

Map of how to get from Saint Charles to Des Moines.

Launch map view

Distance: 286.6 mi
Duration: 5h 50m

What companies run services between Saint Charles, MO, USA and Des Moines, IA, USA?

United Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM) hourly. Alternatively, you can take a vehicle from Saint Charles to Des Moines via 4375 Rider Trail North Sb, North Hanley Transit Center, Civic Center Transit Center, St Louis Bus Station, Kansas City Bus Station, and Kansas City in around 11h 6m.

Airlines

Train operators

Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.