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How to get fromSaint Charles to Destinby plane, bus, train, taxi, or car

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There are 7 ways to get from Saint Charles to Destin by plane, bus, train, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Destin–Fort Walton Beach Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    3h 55m
    $124–499

  2. Bus, train, taxi

    1. Take the bus from St Louis Bus Station to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    3. Take the bus from Gulfport to Crestviewbus bus
    4. Take the taxi from Crestview to Destintaxi taxi
    25h 33m
    $266–399

  3. Bus, train, taxi via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the train from Carbondale to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train
    4. Take the bus from Mobile to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    26h 5m
    $333–659

  4. Drive  752.8 mi

    1. Drive from Saint Charles to Destincar car 752.8 mi
    13h 21m
    $138–199

  5. Fly Lambert–St. Louis International Airport to Northwest Florida Beaches International Airport, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    2. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    4h 38m
    $224–634

  6. Fly Lambert–St. Louis International Airport to Pensacola International Airport, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    2. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    4h 47m
    $184–504

  7. Train to Midamerica St. Louis Airport, fly to Destin–Fort Walton Beach Airport

    1. Take the train from NORTH HANLEY station to SHILOH-SCOTT stationtrain train
    2. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    5h 3m
    $132–467

Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar43Weekly Planes
Duration3h 21mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Destin.ExpandLaunch map view
  • Distance: 642.1 mi
  • Duration: 3h 55m

What companies run services between Saint Charles, MO, USA and Destin, FL, USA?

Southwest Airlines and Delta fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS) every 4 hours.

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