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How to get fromSaint Charles to Gatlinburgby plane, taxi, bus, or car

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There are 7 ways to get from Saint Charles to Gatlinburg by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, taxi

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    2. Take the taxi from Mcghee Tyson Airport (TYS) to Gatlinburgtaxi taxi
    6h 51m
    $294–964

  2. Drive 537.1 mi

    cheapest
    1. Drive from Saint Charles to Gatlinburgcar car 537.1 mi
    9h 20m
    $98–142

  3. Bus, drive

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Gatlinburgcar car
    26h 29m
    $170–335

  4. Fly to Asheville Regional Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Asheville Regional Airport (AVL)plane plane STL - AVL
    2. Drive from Asheville-Airport-AVL to Gatlinburgcar car
    7h 23m
    $109–507

  5. Fly to Nashville, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    2. Drive from Nashville-Airport-BNA to Gatlinburgcar car
    6h 40m
    $119–659

  6. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP)plane plane STL - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Gatlinburgcar car
    7h 56m
    $148–744

  7. Bus, drive via Columbus (Greyhound)

    1. Take the bus from St Louis Bus Station to Columbusbus bus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Gatlinburgcar car
    27h 29m
    $160–320

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar113Weekly Planes
Duration5h 2mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Gatlinburg.ExpandLaunch map view
  • Distance: 460.3 mi
  • Duration: 6h 51m

What companies run services between Saint Charles, MO, USA and Gatlinburg, TN, USA?

There is no direct connection from Saint Charles to Gatlinburg. However, you can take the line 34 bus to North Hanley Transit Center, walk to NORTH HANLEY station, take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Gatlinburg. Alternatively, you can take a bus from 4375 Rider Trail North Sb to Gatlinburg via North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St Louis Bus Station, Atlanta Bus Station, Winston Salem(Trans Center), and Asheville, NC in around 26h 29m.

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