There are 3 ways to get from Saint Charles to Indianapolis by bus (Greyhound), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus (Greyhound)
best- Take the bus from St Louis Bus Station to Indianapolis Union Stationbus Greyhound US0421
6h 53m$57–85Drive 255.1 mi
cheapest- Drive from Saint Charles to Indianapoliscar 255.1 mi
4h 19m$47–68Fly
- Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane STL - IND
6h 27m$879–922
Lambert–St. Louis International Airport (STL) to Indianapolis (IND) flights
Comparing Your Travel Options
The cheapest way to get from Saint Charles to Indianapolis is to drive which costs $45 - $70 and takes 4h 19m.
The fastest way to get from Saint Charles to Indianapolis is to drive which takes 4h 19m and costs $45 - $70.
No, there is no direct bus from Saint Charles to Indianapolis station. However, there are services departing from 4375 Rider Trail North Sb and arriving at Indianapolis Union Station via St Louis Bus Station. The journey, including transfers, takes approximately 6h 53m.
The distance between Saint Charles and Indianapolis is 273 miles. The road distance is 256.5 miles.
The best way to get from Saint Charles to Indianapolis without a car is to bus which takes 6h 53m and costs $55 - $85.
It takes approximately 6h 53m to get from Saint Charles to Indianapolis, including transfers.
Saint Charles to Indianapolis bus services, operated by Greyhound USA, depart from St Louis Bus Station.
The best way to get from Saint Charles to Indianapolis is to bus which takes 6h 53m and costs $55 - $85. Alternatively, you can fly, which costs $870 - $930 and takes 6h 27m.
Saint Charles to Indianapolis bus services, operated by Greyhound USA, arrive at Indianapolis Union Station.
Indianapolis is 1h ahead of Saint Charles. It is currently 9:15 PM in Saint Charles and 10:15 PM in Indianapolis.
What companies run services between Saint Charles, MO, USA and Indianapolis, IN, USA?
Greyhound USA operates a bus from St Louis Bus Station to Indianapolis Union Station 3 times a day. Tickets cost $40–65 and the journey takes 4h 45m. Alternatively, Southwest Airlines, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND) hourly.
- Website
- united.com
Flights from Lambert–St. Louis International Airport to Indianapolis via Chicago O'Hare
- Ave. Duration
- 3h 56m
- When
- Every day
- Estimated price
- $90–550
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Indianapolis via Detroit
- Ave. Duration
- 3h 45m
- When
- Every day
- Estimated price
- $110–650
Flights from Lambert–St. Louis International Airport to Indianapolis via Atlanta
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $130–700
Flights from Lambert–St. Louis International Airport to Indianapolis via Minneapolis
- Ave. Duration
- 4h 33m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $140–750
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Indianapolis via Chicago Midway
- Ave. Duration
- 3h 30m
- When
- Saturday
- Estimated price
- $90–550
Flights from Lambert–St. Louis International Airport to Indianapolis via Nashville
- Ave. Duration
- 4h 26m
- When
- Sunday, Monday, Thursday, Friday, Tuesday, and Wednesday
- Estimated price
- $100–600
Flights from Lambert–St. Louis International Airport to Indianapolis via Kansas City
- Ave. Duration
- 4h 20m
- When
- Tuesday and Wednesday
- Estimated price
- $110–650
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Indianapolis via Chicago O'Hare
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $90–550
Flights from Lambert–St. Louis International Airport to Indianapolis via Charlotte
- Ave. Duration
- 4h 49m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $140–750
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from St Louis Bus Station to Indianapolis Union Station
- Ave. Duration
- 4h 45m
- Frequency
- 3 times a day
- Estimated price
- $40–65
- Website
- Greyhound
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Booking & Getting There
Yes, the driving distance between Saint Charles to Indianapolis is 257 miles. It takes approximately 4h 19m to drive from Saint Charles to Indianapolis.
There are 751+ hotels available in Indianapolis.