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How to get fromSaint Charles to Lexingtonby plane, car, or bus

Find Transport to Lexington

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There are 7 ways to get from Saint Charles to Lexington by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport, drive

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    6h 33m
    $118–625

  2. Drive 359.1 mi

    cheapest
    1. Drive from Saint Charles to Lexingtoncar car 359.1 mi
    6h 9m
    $66–95

  3. Bus, drive

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville, IN to Corydon, INbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    11h 45m
    $133–200

  4. Fly to Covington, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Covington (CVG)plane plane STL - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    6h 24m
    $139–726

  5. Fly to Blue Grass Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    8h 8m
    $186–1,006

  6. Bus, drive via Civic Center Transit Center

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville, IN to Corydon, INbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    12h 18m
    $131–198

  7. Bus, drive via Louisville

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville, IN to Corydon, INbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    12h 46m
    $134–198

Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) flights

Calendar111Weekly Planes
Duration4h 34mAverage Duration
Ticket$104Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Lexington.ExpandLaunch map view
  • Distance: 348.9 mi
  • Duration: 6h 33m

What companies run services between Saint Charles, MO, USA and Lexington, KY, USA?

American Airlines, United Airlines, and Delta fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX) hourly.

Airlines
Bus operators

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