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How to get fromSaint Charles to Lexingtonby plane, car, or bus

Find Transport to Lexington

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There are 8 ways to get from Saint Charles to Lexington by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport, drive

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    6h 26m
    $141–741

  2. Drive  359.1 mi

    cheapest
    1. Drive from Saint Charles to Lexingtoncar car 359.1 mi
    6h 9m
    $66–95

  3. Bus, drive

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville, IN to Corydon, INbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    11h 53m
    $149–266

  4. Fly to Covington, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Covington (CVG)plane plane STL - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    6h 32m
    $142–742

  5. Fly to Blue Grass Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    8h 3m
    $94–452

  6. Fly to John Glenn Columbus International Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to John Glenn Columbus International Airport (CMH)plane plane STL - CMH
    2. Drive from Columbus-Airport-CMH to Lexingtoncar car
    6h 43m
    $137–625

  7. Bus, drive via Civic Center Transit Center

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville, IN to Corydon, INbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    12h 25m
    $147–264

  8. Bus, drive via Louisville

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville, IN to Corydon, INbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    12h 54m
    $150–264

Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) flights

Calendar103Weekly Planes
Duration3h 57mAverage Duration
Ticket$113Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Saint Charles to Lexington.ExpandLaunch map view
  • Distance: 353.3 mi
  • Duration: 6h 26m

What companies run services between Saint Charles, MO, USA and Lexington, KY, USA?

Delta, United Airlines, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX) hourly.

Airlines
Bus operators

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