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How to get fromSaint Charles to Louisvilleby bus (Greyhound), car, or plane

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There are 4 ways to get from Saint Charles to Louisville by bus (Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus Greyhound US0185 / ...
    2. Take the bus from Evansville, IN to Louisville, KYbus bus Evansville
    9h 21m
    $80–193

  2. Drive  280.4 mi

    cheapest
    1. Drive from Saint Charles to Louisvillecar car 280.4 mi
    4h 40m
    $52–74

  3. Fly to Louisville International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    6h 8m
    $138–823

  4. Fly to Blue Grass Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 58m
    $105–479

Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) flights

Calendar90Weekly Planes
Duration4h 26mAverage Duration
Ticket$127Cheapest Price
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Comparing Your Travel Options

Map of how to get from Saint Charles to Louisville.ExpandLaunch map view
  • Distance: 312.9 mi
  • Duration: 9h 21m

What companies run services between Saint Charles, MO, USA and Louisville, KY, USA?

You can take a vehicle from Saint Charles to Louisville, KY via 4375 Rider Trail North Sb, North Hanley Transit Center, Civic Center Transit Center, St Louis Bus Station, and Evansville, IN in around 9h 21m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) hourly.

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