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How to get fromSaint Charles to Louisvilleby bus (Greyhound), car, plane, or bus

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There are 5 ways to get from Saint Charles to Louisville by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus Greyhound US0185 / ...
    2. Take the bus from Evansville, IN to Louisville, KYbus bus Evansville / ...
    8h 29m
    $65–109

  2. Drive 280.4 mi

    cheapest
    1. Drive from Saint Charles to Louisvillecar car 280.4 mi
    4h 40m
    $52–74

  3. Fly to Louisville International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    6h 15m
    $105–607

  4. Fly to Blue Grass Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    7h 3m
    $197–1,023

  5. Fly to Nashville, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    2. Take the bus from Nashville Bus Station to Louisville Bus Stationbus bus
    7h 5m
    $113–531

Saint Charles to Louisville by bus and train

Calendar14Weekly Services
Duration8h 29mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Louisville.ExpandLaunch map view
  • Distance: 303.8 mi
  • Duration: 8h 29m

What companies run services between Saint Charles, MO, USA and Louisville, KY, USA?

You can take a bus from Riverport Lane @ Riverport Eb to Louisville, KY via North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St Louis Bus Station, and Evansville, IN in around 8h 29m. Alternatively, Southwest Airlines, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) hourly.

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