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How to get fromSaint Charles to Niagara Fallsby plane, bus, bus (Greyhound), car, or train

Find Transport to Niagara Falls

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There are 7 ways to get from Saint Charles to Niagara Falls by plane, bus, bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    2. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    7h 21m
    $131–677

  2. Fly to Toronto Island Airport, bus

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Island Airport (YTZ)plane plane STL - YTZ
    2. Take the bus from Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floor to Bus Terminalbus bus
    9h 35m
    $100–496

  3. Bus

    1. Take the bus from St Louis Bus Station to Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus - Mound St to Buffalo, NYbus bus Cinncinati,OH-Buffalo / ...
    22h 29m
    $119–211

  4. Drive  765.8 mi

    1. Drive from Saint Charles to Niagara Fallscar car 765.8 mi
    13h 8m
    $140–202

  5. Fly to Toronto Pearson International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Pearson International Airport (YYZ)plane plane STL - YYZ
    2. Take the bus from Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floor to Bus Terminalbus bus
    7h 27m
    $101–475

  6. Fly to Rochester, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)plane plane STL - ROC
    2. Take the train from Rochester to Niagara Falls Amtrak Stationtrain train
    8h 52m
    $219–1,112

  7. Bus via Pittsburgh

    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus Greyhound US0421
    2. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    27h 2m
    $159–362

Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF) flights

Calendar103Weekly Planes
Duration4h 49mAverage Duration
Ticket$117Cheapest Price
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Comparing Your Travel Options

Map of how to get from Saint Charles to Niagara Falls.ExpandLaunch map view
  • Distance: 724.9 mi
  • Duration: 7h 21m

What companies run services between Saint Charles, MO, USA and Niagara Falls, NY, USA?

You can take a vehicle from Saint Charles to Main Street & Pine Avenue via Riverport Lane @ Riverport Eb, North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St Louis Bus Station, Columbus - Mound St, and Ellicott Street & MTC Static in around 22h 29m.

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