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How to get fromSaint Charles to Nilesby bus, plane, train (Amtrak), bus (Flixbus), car, subway, or train

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There are 6 ways to get from Saint Charles to Niles by bus, plane, train (Amtrak), bus (Flixbus), car, subway, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 34 bus, fly to Chicago O'Hare International Airport, bus

    best
    1. Take the bus from 4375 Rider Trail North Sb to North Hanley Transit Centerbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    3. Take the bus from Jefferson Park Transit Center to Harlem Stationbus bus
    3h 46m
    $277–712

  2. Drive 311.5 mi

    cheapest
    1. Drive from Saint Charles to Nilescar car 311.5 mi
    5h 26m
    $57–83

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    8h 5m
    $100–205

  4. Bus (Flixbus)

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
    8h 57m
    $92–142

  5. Line 34 bus, fly to Chicago Midway International Airport, subway, bus

    1. Take the bus from 4375 Rider Trail North Sb to North Hanley Transit Centerbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    3. Take the subway from Clark/Lake to Jefferson Parksubway subway
    4. Take the bus from Jefferson Park Transit Center to Harlem Stationbus bus
    4h 27m
    $64–387

  6. Train, bus

    1. Take the train from St. Louis to Bloomington-Normaltrain train Lincoln Service / ...
    2. Take the bus from Uptown Station to O'Hare International Terminal 2bus bus Peoria line
    9h 33m
    $102–182

Saint Charles to Niles by bus, train, and subway (Amtrak)

Calendar38Weekly Services
Duration8h 5mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Niles.ExpandLaunch map view
  • Distance: 287 mi
  • Duration: 3h 46m

What companies run services between Saint Charles, MO, USA and Niles, IL, USA?

Amtrak operates a train from St. Louis to Chicago Union Station 5 times a day. Tickets cost $90–190 and the journey takes 4h 55m. Alternatively, Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station 4 times a day. Tickets cost $50–85 and the journey takes 6h 5m.

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