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How to get fromSaint Charles to Panama City Beachby plane, bus (Greyhound, Flixbus), or car

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There are 4 ways to get from Saint Charles to Panama City Beach by plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    3h 56m
    $144–549

  2. Fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    4h 51m
    $99–490

  3. Bus

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    22h 3m
    $143–276

  4. Drive 760.1 mi

    1. Drive from Saint Charles to Panama City Beachcar car 760.1 mi
    13h 49m
    $139–201

Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) flights

Calendar31Weekly Planes
Duration2h 57mAverage Duration
Ticket$91Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Panama City Beach.ExpandLaunch map view
  • Distance: 670 mi
  • Duration: 3h 56m

What companies run services between Saint Charles, MO, USA and Panama City Beach, FL, USA?

Southwest Airlines and Delta fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) 4 times a day. Alternatively, you can take a bus from Riverport Lane @ Riverport Eb to Panama City Beach via North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St Louis Bus Station, Nashville Bus Station, Tallahassee, and Panama City Beach Bus Station in around 22h 3m.

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