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How to get fromSaint Charles to Pittsburghby bus, plane, train (Amtrak), bus (Greyhound), or car

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There are 4 ways to get from Saint Charles to Pittsburgh by bus, plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 34 bus, fly, bus

    best
    1. Take the bus from 4375 Rider Trail North Sb to North Hanley Transit Centerbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Pittsburgh International Airport (PIT)plane plane STL - PIT
    3. Take the bus from Pittsburgh International Airport to Seventh Ave + William Penn Plbus bus
    4h 54m

  2. Drive  612.3 mi

    cheapest
    1. Drive from Saint Charles to Pittsburghcar car 612.3 mi
    10h 25m
    $112–162

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train Floridian
    17h 15m
    $427–669

  4. Bus (Greyhound)

    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus Greyhound US0421
    17h 21m
    $115–188

Lambert–St. Louis International Airport (STL) to Pittsburgh International Airport (PIT) flights

Calendar56Weekly Planes
Duration3h 3mAverage Duration
Ticket$90Cheapest Price
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Comparing Your Travel Options

Map of how to get from Saint Charles to Pittsburgh.ExpandLaunch map view
  • Distance: 597.5 mi
  • Duration: 4h 54m

What companies run services between Saint Charles, MO, USA and Pittsburgh, PA, USA?

You can take a vehicle from Saint Charles to Pittsburgh Amtrak Station via Riverport Lane @ Riverport Eb, North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St. Louis, and Chicago Union Station in around 17h 15m. Alternatively, Greyhound USA operates a bus from St Louis Bus Station to Pittsburgh Intermodal Station 3 times a day. Tickets cost $100–170 and the journey takes 14h 40m.

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