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How to get fromSaint Charles to Pittsburghby plane, bus, bus (Greyhound), train (Amtrak), or car

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There are 4 ways to get from Saint Charles to Pittsburgh by plane, bus, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Pittsburgh International Airport (PIT)plane plane STL - PIT
    2. Take the bus from Pittsburgh International Airport to Seventh Ave + William Penn Plbus bus
    4h 48m

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus Greyhound US0421
    16h 41m
    $89–174

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train Floridian
    17h 9m
    $209–484

  4. Drive 612.3 mi

    1. Drive from Saint Charles to Pittsburghcar car 612.3 mi
    10h 25m
    $112–162

Saint Charles to Pittsburgh by bus and train (Greyhound)

Calendar21Weekly Services
Duration16h 41mAverage Duration
Ticket$89Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Pittsburgh.ExpandLaunch map view
  • Distance: 593.1 mi
  • Duration: 4h 48m

What companies run services between Saint Charles, MO, USA and Pittsburgh, PA, USA?

Greyhound USA operates a bus from St Louis Bus Station to Pittsburgh Intermodal Station 3 times a day. Tickets cost $85–170 and the journey takes 14h 40m. Alternatively, you can take a bus from Riverport Lane @ Riverport Eb to Pittsburgh Amtrak Station via North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St. Louis, and Chicago Union Station in around 17h 9m.

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