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How to get fromSaint Charles to Rochesterby plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, or bus (Greyhound)

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There are 6 ways to get from Saint Charles to Rochester by plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)plane plane STL - ROC
    5h 34m
    $179–873

  2. Bus

    cheapest
    1. Take the bus from St Louis Bus Station to Columbusbus bus
    2. Take the bus from Columbus - Mound St to Buffalo, NYbus bus
    3. Take the bus from Buffalo to Rochester Bus Stopbus bus
    22h 58m
    $114–235

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Rochestertrain train Lake Shore Limited
    19h 14m
    $284–584

  4. Drive 814.1 mi

    1. Drive from Saint Charles to Rochestercar car 814.1 mi
    14h 13m
    $149–215

  5. Fly to Buffalo Niagara International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    2. Take the bus from Buffalo Niagara International Airport to Rochester Bus Stopbus bus
    7h 18m
    $174–871

  6. Bus via Pittsburgh

    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus
    2. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    3. Take the bus from Buffalo to Rochesterbus bus 325
    27h 21m
    $163–434

Saint Charles to Rochester by bus and train (Amtrak)

Calendar14Weekly Services
Duration19h 14mAverage Duration
Ticket$284Cheapest Price
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Questions & Answers

Map of how to get from Saint Charles to Rochester.ExpandLaunch map view
  • Distance: 748.2 mi
  • Duration: 5h 34m

What companies run services between Saint Charles, MO, USA and Rochester, NY, USA?

Delta, Southwest Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC) hourly. Alternatively, you can take a bus from Riverport Lane @ Riverport Eb to Rochester via North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St. Louis, and Chicago Union Station in around 19h 14m.

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