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How to get fromSaint Charles to Rochesterby plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, or bus (Greyhound)

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There are 6 ways to get from Saint Charles to Rochester by plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)plane plane STL - ROC
    5h 38m
    $117–499

  2. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Rochestertrain train Lake Shore Limited
    19h 20m
    $487–759

  3. Bus

    1. Take the bus from St Louis Bus Station to Columbusbus bus
    2. Take the bus from Columbus to Buffalobus bus
    3. Take the bus from Buffalo to Rochester Bus Stopbus bus
    24h 21m
    $137–239

  4. Drive  818 mi

    1. Drive from Saint Charles to Rochestercar car 818 mi
    14h 4m
    $140–202

  5. Fly to Buffalo Niagara International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    2. Take the bus from Buffalo Niagara International Airport to Rochester Bus Stopbus bus
    7h 39m
    $157–736

  6. Bus via Pittsburgh

    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus
    2. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    3. Take the bus from Buffalo to Rochesterbus bus 325
    28h 13m
    $191–430

Lambert–St. Louis International Airport (STL) to Rochester (ROC) flights

Calendar129Weekly Planes
Duration5h 2mAverage Duration
Ticket$86Cheapest Price
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Comparing Your Travel Options

Map of how to get from Saint Charles to Rochester.ExpandLaunch map view
  • Distance: 752.6 mi
  • Duration: 5h 38m

What companies run services between Saint Charles, MO, USA and Rochester, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC) hourly. Alternatively, you can take a vehicle from Saint Charles to Rochester via Riverport Lane @ Riverport Eb, North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St. Louis, and Chicago Union Station in around 19h 20m.

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Want to know more about travelling around United States

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