Rome2Rio

How to get fromSaint Charles to Winston-Salemby plane, bus (Greyhound, Flixbus), car, bus, or bus (Greyhound)

Find Transport to Winston-Salem

See all options

There are 6 ways to get from Saint Charles to Winston-Salem by plane, bus (Greyhound, Flixbus), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO)plane plane STL - GSO
    6h 43m
    $173–827

  2. Drive 700 mi

    cheapest
    1. Drive from Saint Charles to Winston-Salemcar car 700 mi
    12h 46m
    $128–185

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus Greyhound US0670
    21h 1m
    $134–269

  4. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 47m
    $135–750

  5. Fly to Raleigh-Durham International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)plane plane STL - RDU
    2. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    7h 39m
    $572–1,034

  6. Bus via Columbus (Greyhound)

    1. Take the bus from St Louis Bus Station to Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus Greyhound US0140
    22h 1m
    $129–264

Saint Charles to Winston-Salem by bus and train

Calendar12Weekly Services
Duration21h 1mAverage Duration
Ticket$134Cheapest Price
See schedules

Questions & Answers

Map of how to get from Saint Charles to Winston-Salem.ExpandLaunch map view
  • Distance: 639.6 mi
  • Duration: 6h 43m

What companies run services between Saint Charles, MO, USA and Winston-Salem, NC, USA?

Delta, American Airlines, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from 4375 Rider Trail North Sb to Winston Salem(Trans Center) via North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St Louis Bus Station, and Atlanta Bus Station in around 21h 1m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers